Targeting Epstein-Barr virus in nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is consistently associated with Epstein-Barr virus (EBV)
infection in regions in which it is endemic, including Southern China and Southeast Asia …
infection in regions in which it is endemic, including Southern China and Southeast Asia …
Dominant-negative HIF-3α4 suppresses VHL-null renal cell carcinoma progression
The most prevalent mutations associated with the development of clear-cell renal cell
carcinoma (CC-RCC) are the loss-of-function mutations of von Hippel-Lindau (VHL) tumor …
carcinoma (CC-RCC) are the loss-of-function mutations of von Hippel-Lindau (VHL) tumor …
Inhibition of glucocorticoid-induced apoptosis by targeting the major splice variants of BIM mRNA with small interfering RNA and short hairpin RNA
MT Abrams, NM Robertson, K Yoon… - Journal of Biological …, 2004 - ASBMB
Glucocorticoids (GCs) induce apoptosis in lymphocytes and are effective agents for the
treatment of leukemia. The activated glucocorticoid receptor initiates a transcriptional …
treatment of leukemia. The activated glucocorticoid receptor initiates a transcriptional …
Benzethonium chloride: a novel anticancer agent identified by using a cell-based small-molecule screen
KW Yip, X Mao, PYB Au, DW Hedley, S Chow… - Clinical Cancer …, 2006 - AACR
Purpose: This study aims to identify a novel therapeutic agent for head and neck cancer and
to evaluate its antitumor efficacy. Experimental Design: A cell-based and phenotype-driven …
to evaluate its antitumor efficacy. Experimental Design: A cell-based and phenotype-driven …
Prognostic significance of the Epstein-Barr virus, p53, Bcl-2, and survivin in nasopharyngeal cancer
Purpose: Nasopharyngeal cancer (NPC) is a malignant epithelial carcinoma which is
intimately associated with EBV. The latent presence of EBV affects the function of p53, Bcl-2 …
intimately associated with EBV. The latent presence of EBV affects the function of p53, Bcl-2 …
Multiple dysregulated pathways in nasopharyngeal carcinoma revealed by gene expression profiling
W Shi, C Bastianutto, A Li… - … journal of cancer, 2006 - Wiley Online Library
Gene expression profiling was conducted using primary human nasopharyngeal carcinoma
(NPC) biopsy samples to improve the understanding of the molecular pathways defining …
(NPC) biopsy samples to improve the understanding of the molecular pathways defining …
Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent
KW Yip, E Ito, X Mao, PYB Au, DW Hedley… - Molecular cancer …, 2006 - AACR
Despite advances in surgery, radiation, and chemotherapy, novel therapeutics are needed
for head and neck cancer treatment. The objective of this current study was to evaluate …
for head and neck cancer treatment. The objective of this current study was to evaluate …
Combination bcl-2 antisense and radiation therapy for nasopharyngeal cancer
Purpose: A wide variety of tumors depend on the dysregulation of Bcl-2 family proteins for
survival. The resulting apoptotic block can often provide a mechanism for resistance to …
survival. The resulting apoptotic block can often provide a mechanism for resistance to …
Radiogenic therapy: novel approaches for enhancing tumor radiosensitivity
T Robson, J Worthington… - … in cancer research & …, 2005 - journals.sagepub.com
Radiotherapy (RT) is a well established modality for treating many forms of cancer.
However, despite many improvements in treatment planning and delivery, the total radiation …
However, despite many improvements in treatment planning and delivery, the total radiation …
Involvement of reactive oxygen species/c-Jun NH2-terminal kinase pathway in kotomolide A induces apoptosis in human breast cancer cells
The anticancer effects of kotomolide A (KTA), a new butanolide constituent isolated from the
leaves of Cinnamomum kotoense (Lauraceae), on the two human breast cancer cell lines …
leaves of Cinnamomum kotoense (Lauraceae), on the two human breast cancer cell lines …