Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and
progression. In this review, we update currents concepts of hypoxia-induced alternative …

Anti-apoptotic B cell lymphoma 2 (BCL2) family members (BCL2, MCL1, BCLxL, BCLW, and
BFL1) are key players in the regulation of intrinsic apoptosis. Dysregulation of these proteins …

The RNA-mediated disease model for myotonic dystrophy (DM) proposes that microsatellite
C (C) TG expansions express toxic RNAs that disrupt splicing regulation by altering MBNL1 …

Bcl-xL is a pro-survival protein of the Bcl2 family found in the mitochondrial membrane. Bcl-
xL supports growth, development, and maturation of neurons, and it also prevents neuronal …

Aim Aggravated neuronal loss, caused mainly by neuronal apoptosis, is observed in the
brain of patients with Alzheimer's disease (AD) and animal models of AD. A truncated form of …

Maintenance of oxygen homeostasis is an indispensable criterion for the existence of
multicellular life-forms. Disruption of this homeostasis due to inadequate oxygenation of the …

Gene splicing modulates the potency of cell death effectors, alters neuropathological
disease processes, influences neuronal recovery, but may also direct distinct mechanisms of …

Resumen DRASTICHOVA, Zdenka; RUDAJEV, Vladimir; PALLAG, Gergely y NOVOTNY,
Jiri. Proteome profiling of different rat brain regions reveals the modulatory effect of …

RNA splicing takes place in the nucleus and occurs either co-or post-transcriptionally.
Noncoding sequences (introns) in nuclear mRNA precursors (pre-mRNA) are removed by …

Diabetes is a consequence of reduced β-cell function and mass, due to β-cell apoptosis.
Endoplasmic reticulum (ER) stress is induced during β-cell apoptosis due to various stimuli …