Valvular heart disease is a major cause of morbidity and mortality worldwide. Surgical valve
repair or replacement has been the standard of care for patients with valvular heart disease …

Electrospinning is a versatile technique in tissue engineering for the production of scaffolds.
To guide tissue development, scaffolds must provide specific biochemical, structural and …

Polycaprolactone (PCL) is a biocompatible aliphatic polyester with many possible
applications in the medical field. PCL nanofibres, produced by electrospinning, could …

The current clinical solutions, including mechanical and bioprosthetic valves for valvular
heart diseases, are plagued by coagulation, calcification, nondurability, and the inability to …

Cardiovascular disease (CVD) is a general term for conditions which are the leading cause
of death in the world. Quick restoration of tissue perfusion is a key factor to combat these …

Surgical replacement of diseased heart valves by mechanical and tissue valve substitutes is
now commonplace and enhances survival and quality of life for many patients. However …

The field of melt electrowriting (MEW) has seen significant progress, bringing innovative
advancements to the fabrication of biomaterial scaffolds, and creating new possibilities for …

The development of living heart valves that grow with the patient is a promising strategy for
heart valve replacements in pediatric patients. Despite active research in the field of tissue …

Materials currently used to repair or replace a heart valve are not durable. Their limited
durability related to structural degeneration or thrombus formation is attributed to their …

The development of three-dimensional (3D) scaffolds with physical and chemical topological
cues at the macro-, micro-, and nanometer scale is urgently needed for successful tissue …