RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their
malfunction underlies the origin of many diseases. RBPs can recognize hundreds of …

Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation
1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat …

MicroRNAs (miRNAs) are a conserved class of small non-coding RNAs that assemble with
Argonaute proteins into miRNA-induced silencing complexes (miRISCs) to direct post …

Activity-dependent translation requires the transport of mRNAs within membraneless protein
assemblies known as neuronal granules from the cell body toward synaptic regions …

Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS),
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …

Autism spectrum disorder (ASD) encompasses a group of multifactorial neurodevelopmental
disorders characterized by impaired social communication, social interaction and repetitive …

INTRODUCTION RNA sequencing and in situ hybridization have revealed the presence of
an unexpectedly high number of RNA species in neuronal dendrites and axons, and many …

MicroRNAs (miRNAs) are small RNAs that control gene expression through silencing of
target mRNAs. Mature miRNAs are processed from primary miRNA transcripts by the …

The molecular components of the postsynaptic density (PSD) in excitatory synapses of the
brain are currently being investigated as one of the major etiologies of neurodevelopmental …

Brain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission
and long-term potentiation (LTP) in the hippocampus and in other brain regions, playing a …