Among sulfur containing heterocycles, benzothiophene and its derivatives are at the focus
as these candidates have structural similarities with active compounds to develop new …

Tubulin dynamics is a promising target for new chemotherapeutic agents. The colchicine
binding site is one of the most important pockets for potential tubulin polymerization …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Iodine has been recognized as an efficient, non-toxic, readily available and easy-to-handle
electrophilic reagent to favour halocyclization reactions for the synthesis of novel …

The reaction of 3-chlorobenzo [b] thiophene-2-carbohydrazide with 4-(diethylamino)
salicylaldehyde gave the new ligand; 3-chloro-N'-(4-(diethylamino)-2-hydroxybenzylidene) …

amino-N-cyclopropyl-5-ethylthiophene-3-carboxamide (ACPETC)(C 10 H 14 N 2 OS) has
been synthesized, characterized via single-crystal X-ray diffraction at 296 K and studied …

A copper-catalyzed thiolation annulation reaction of 2-bromo alkynylbenzenes with sodium
sulfide has been developed. In the presence of CuI and TMEDA, a variety of 2-substituted …

Since microtubules have an important role in mitosis and other vital cellular functions,
tubulin-targeting chemotherapy has been received growing attention in anticancer drug …

The development of chalcones as antimitotic agents has led to the design of other
analogues able to interact with tubulin and inhibit its assembly into microtubules. This …

In recent times cancer has become one of the leading causes of death. Globally around 11
million deaths are reported every year due to cancer. Some clinically approved anticancer …