Therapeutic targets in lung tissue remodelling and fibrosis
Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
[HTML][HTML] Interferon-gamma (IFN-γ): Exploring its implications in infectious diseases
A key player in driving cellular immunity, IFN-γ is capable of orchestrating numerous
protective functions to heighten immune responses in infections and cancers. It can exhibit …
protective functions to heighten immune responses in infections and cancers. It can exhibit …
[HTML][HTML] Inflammation and immunity in IPF pathogenesis and treatment
P Heukels, CC Moor, JH Von der Thüsen… - Respiratory …, 2019 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive, and ultimately fatal, chronic interstitial
lung disease characterized by enhanced extracellular matrix deposition. Repetitive alveolar …
lung disease characterized by enhanced extracellular matrix deposition. Repetitive alveolar …
Fibrosis—a common pathway to organ injury and failure
DC Rockey, PD Bell, JA Hill - New England Journal of Medicine, 2015 - Mass Medical Soc
Fibrosis — A Common Pathway to Organ Injury and Failure | NEJM Skip to main content NEJM
Group Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare to become a …
Group Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare to become a …
Disrupting mechanotransduction decreases fibrosis and contracture in split-thickness skin grafting
Burns and other traumatic injuries represent a substantial biomedical burden. The current
standard of care for deep injuries is autologous split-thickness skin grafting (STSG), which …
standard of care for deep injuries is autologous split-thickness skin grafting (STSG), which …
An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management
G Raghu, HR Collard, JJ Egan, FJ Martinez… - American journal of …, 2011 - atsjournals.org
This document is an international evidence-based guideline on the diagnosis and
management of idiopathic pulmonary fibrosis, and is a collaborative effort of the American …
management of idiopathic pulmonary fibrosis, and is a collaborative effort of the American …
[HTML][HTML] The role of immune and inflammatory cells in idiopathic pulmonary fibrosis
The contribution of the immune system to idiopathic pulmonary fibrosis (IPF) remains poorly
understood. While most sources agree that IPF does not result from a primary …
understood. While most sources agree that IPF does not result from a primary …
Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials
PW Noble, C Albera, WZ Bradford, U Costabel… - The Lancet, 2011 - thelancet.com
Background Idiopathic pulmonary fibrosis is a progressive and fatal lung disease with
inevitable loss of lung function. The CAPACITY programme (studies 004 and 006) was …
inevitable loss of lung function. The CAPACITY programme (studies 004 and 006) was …
Clinical course and prediction of survival in idiopathic pulmonary fibrosis
B Ley, HR Collard, TE King Jr - American journal of respiratory and …, 2011 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a progressive, life-threatening, interstitial lung disease
of unknown etiology. The median survival of patients with IPF is only 2 to 3 years, yet some …
of unknown etiology. The median survival of patients with IPF is only 2 to 3 years, yet some …
The impact of TGF-β on lung fibrosis: from targeting to biomarkers
IE Fernandez, O Eickelberg - Proceedings of the American Thoracic …, 2012 - atsjournals.org
Transforming growth factor-β (TGF-β) is extensively involved in the development of fibrosis
in different organs. Overproduction or potentiation of its profibrotic effects leads to an …
in different organs. Overproduction or potentiation of its profibrotic effects leads to an …