Fatty acids are metabolized and synthesized as energy substrates during biological
responses. Long-and medium-chain fatty acids derived mainly from dietary triglycerides, and …

Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy.
Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute …

A valuable approach to chemical safety assessment is the use of read-across chemicals to
provide safety data to support the assessment of structurally similar chemicals. An inventory …

Alzheimer's disease (AD) risk gene ApoE4 perturbs brain lipid homeostasis and energy
transduction. However, the cell-type-specific mechanism of ApoE4 in modulating brain lipid …

Many of the internal organ systems of Drosophila melanogaster are functionally analogous
to those in vertebrates, including humans. Although humans and flies differ greatly in terms …

Adipose tissue is a complex, multicellular organ that profoundly influences the function of
nearly all other organ systems through its diverse metabolite and adipokine secretome …

The intracellular storage and utilization of lipids are critical to maintain cellular energy
homeostasis. During nutrient deprivation, cellular lipids stored as triglycerides in lipid …

Adipose tissue plays a central role in regulating whole-body energy and glucose
homeostasis through its subtle functions at both organ and systemic levels. On one hand …

Tumor cells display progressive changes in metabolism that correlate with malignancy,
including development of a lipogenic phenotype. How stored fats are liberated and …

Lipolysis is the biochemical pathway responsible for the catabolism of triacylglycerol (TAG)
stored in cellular lipid droplets. The hydrolytic cleavage of TAG generates non-esterified fatty …