[HTML][HTML] Free fatty acid receptors in health and disease
Fatty acids are metabolized and synthesized as energy substrates during biological
responses. Long-and medium-chain fatty acids derived mainly from dietary triglycerides, and …
responses. Long-and medium-chain fatty acids derived mainly from dietary triglycerides, and …
Lipid metabolism reprogramming and its potential targets in cancer
Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy.
Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute …
Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute …
Clustering a chemical inventory for safety assessment of fragrance ingredients: identifying read-across analogs to address data gaps
MS Date, D O'Brien, DJ Botelho… - Chemical research in …, 2020 - ACS Publications
A valuable approach to chemical safety assessment is the use of read-across chemicals to
provide safety data to support the assessment of structurally similar chemicals. An inventory …
provide safety data to support the assessment of structurally similar chemicals. An inventory …
[HTML][HTML] ApoE4 impairs neuron-astrocyte coupling of fatty acid metabolism
Alzheimer's disease (AD) risk gene ApoE4 perturbs brain lipid homeostasis and energy
transduction. However, the cell-type-specific mechanism of ApoE4 in modulating brain lipid …
transduction. However, the cell-type-specific mechanism of ApoE4 in modulating brain lipid …
Drosophila tools and assays for the study of human diseases
Many of the internal organ systems of Drosophila melanogaster are functionally analogous
to those in vertebrates, including humans. Although humans and flies differ greatly in terms …
to those in vertebrates, including humans. Although humans and flies differ greatly in terms …
[HTML][HTML] Beyond the cell: The cell biology of fat expansion
Adipose tissue is a complex, multicellular organ that profoundly influences the function of
nearly all other organ systems through its diverse metabolite and adipokine secretome …
nearly all other organ systems through its diverse metabolite and adipokine secretome …
Autophagy regulates lipid metabolism
The intracellular storage and utilization of lipids are critical to maintain cellular energy
homeostasis. During nutrient deprivation, cellular lipids stored as triglycerides in lipid …
homeostasis. During nutrient deprivation, cellular lipids stored as triglycerides in lipid …
[HTML][HTML] Adipose tissue in control of metabolism
L Luo, M Liu - Journal of endocrinology, 2016 - joe.bioscientifica.com
Adipose tissue plays a central role in regulating whole-body energy and glucose
homeostasis through its subtle functions at both organ and systemic levels. On one hand …
homeostasis through its subtle functions at both organ and systemic levels. On one hand …
[HTML][HTML] Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis
Tumor cells display progressive changes in metabolism that correlate with malignancy,
including development of a lipogenic phenotype. How stored fats are liberated and …
including development of a lipogenic phenotype. How stored fats are liberated and …
[HTML][HTML] Lipolysis–a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores
A Lass, R Zimmermann, M Oberer, R Zechner - Progress in lipid research, 2011 - Elsevier
Lipolysis is the biochemical pathway responsible for the catabolism of triacylglycerol (TAG)
stored in cellular lipid droplets. The hydrolytic cleavage of TAG generates non-esterified fatty …
stored in cellular lipid droplets. The hydrolytic cleavage of TAG generates non-esterified fatty …