Single‐cell RNA sequencing technologies and applications: A brief overview
D Jovic, X Liang, H Zeng, L Lin, F Xu… - Clinical and …, 2022 - Wiley Online Library
Single‐cell RNA sequencing (scRNA‐seq) technology has become the state‐of‐the‐art
approach for unravelling the heterogeneity and complexity of RNA transcripts within …
approach for unravelling the heterogeneity and complexity of RNA transcripts within …
Current and future perspectives of liquid biopsies in genomics-driven oncology
Precision oncology seeks to leverage molecular information about cancer to improve patient
outcomes. Tissue biopsy samples are widely used to characterize tumours but are limited by …
outcomes. Tissue biopsy samples are widely used to characterize tumours but are limited by …
Formation and integration of new neurons in the adult hippocampus
A Denoth-Lippuner, S Jessberger - Nature Reviews Neuroscience, 2021 - nature.com
Neural stem cells (NSCs) generate new neurons throughout life in the mammalian brain.
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …
Drosophila Innate Immunity Involves Multiple Signaling Pathways and Coordinated Communication Between Different Tissues
S Yu, F Luo, Y Xu, Y Zhang, LH Jin - Frontiers in Immunology, 2022 - frontiersin.org
The innate immune response provides the first line of defense against invading pathogens,
and immune disorders cause a variety of diseases. The fruit fly Drosophila melanogaster …
and immune disorders cause a variety of diseases. The fruit fly Drosophila melanogaster …
scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells
Parallel single-cell sequencing protocols represent powerful methods for investigating
regulatory relationships, including epigenome-transcriptome interactions. Here, we report a …
regulatory relationships, including epigenome-transcriptome interactions. Here, we report a …
Functions and mechanisms of epigenetic inheritance in animals
The idea that epigenetic determinants such as DNA methylation, histone modifications or
RNA can be passed to the next generation through meiotic products (gametes) is long …
RNA can be passed to the next generation through meiotic products (gametes) is long …
Revealing the vectors of cellular identity with single-cell genomics
Single-cell genomics has now made it possible to create a comprehensive atlas of human
cells. At the same time, it has reopened definitions of a cell's identity and of the ways in …
cells. At the same time, it has reopened definitions of a cell's identity and of the ways in …
Dynamics of the epigenetic landscape during the maternal-to-zygotic transition
MA Eckersley-Maslin, C Alda-Catalinas… - … Reviews Molecular Cell …, 2018 - nature.com
A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …
The kaleidoscope of microglial phenotypes
ML Dubbelaar, L Kracht, BJL Eggen… - Frontiers in …, 2018 - frontiersin.org
Gene expression analyses of microglia, the tissue-resident macrophages of the central
nervous system (CNS), led to the identification of homeostatic as well as neurological …
nervous system (CNS), led to the identification of homeostatic as well as neurological …
Epigenetic regulation in neurodegenerative diseases
Mechanisms of epigenetic regulation, including DNA methylation, chromatin remodeling,
and histone post-translational modifications, are involved in multiple aspects of neuronal …
and histone post-translational modifications, are involved in multiple aspects of neuronal …