Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of skeletal
muscle mass, along with adipose tissue wasting, systemic inflammation and other metabolic …

Metabolic reprogramming occurs in tumors to foster cancer cell proliferation, survival and
metastasis, but as well at a systemic level affecting the whole organism, eventually leading …

Cachexia is a systemic condition that occurs during many neoplastic diseases, such as
cancer. Cachexia in cancer is characterized by loss of body weight and muscle and by …

Adult skeletal tissue is composed of heterogeneous population of cells that constantly self-
renew by means of a controlled process of activation and proliferation of tissue-resident …

Muscle fatigue (MF) declines the capacity of muscles to complete a task over time at a
constant load. MF is usually short-lasting, reversible, and is experienced as a feeling of …

The majority of critically ill intensive care unit (ICU) patients with severe sepsis develop ICU-
acquired weakness (ICUAW) characterized by loss of muscle mass, reduction in myofiber …

Skeletal muscle exhibits great plasticity in response to altered activity levels, ultimately
resulting in tissue remodelling and substantial changes in mass. Animal research would …

Advancements in animal models and cell culture techniques have been invaluable in the
elucidation of the molecular mechanisms that regulate muscle atrophy. However, few …

Calpain is an intracellular Ca2D-dependent cysteine protease (EC 3.4. 22.17; Clan CA,
family C02) discovered in 1964. It was also called CANP (Ca2D-activated neutral protease) …

Sustained periods of negative energy balance decrease body mass due to losses of both fat
and skeletal muscle mass. Decreases in skeletal muscle mass are associated with a myriad …