DNA demethylation and histone hyperacetylation of CD11a and CD70 regulatory regions
contribute to the development of autoreactivity and autoantibody overstimulation in CD4+ T …

Abstract 2019 novel coronavirus (2019-nCoV) with strong contagion in the crowd, has
ravaged worldwide and severely impacts the human health and epidemic prevention …

Transcription factors (TFs) play central roles in the regulation of gene expression through
binding to specific DNA sequences, and may influence multiple transcription-associated …

This study describes a method for analyzing transcription factor (TF) activity, near-infrared
fluorescent solid-phase rolling circle amplification (NIRF-sRCA). This method analyzes TF …

Transcription factors (TFs) are emerging tumor biomarkers that regulate gene expression.
The detection of TFs depends on the transduction of TF-DNA binding to the nucleic acid …

Gastric cancer is one of the leading causes of malignancy-related mortality worldwide, and
drug resistance hampered the clinical efficacy of chemotherapy. To better understand the …

Background The majority of the promoters, their regulatory elements, and their variations in
the human genome remain unknown. Reporter gene technology for transcriptional activity is …

Aurora-A is a serine/threonine protein kinase and plays an important role in the control of
mitotic progression. Dysregulated expression of Aurora-A impairs centrosome separation …

Transcription factors (TFs) are crucial components of regulatory networks that control gene
transcription. Current TF assays are limited to the analysis of a single TF or require TF …

Transcription factors are regulatory proteins that bind to specific sites of chromosomal DNA
to enact responses to intracellular and extracellular stimuli. Transcription factor signalling …