Chlorinated Solvents: Their Advantages, Disadvantages, and Alternatives in Organic and
Medicinal Chemistry | Chemical Reviews ACS ACS Publications C&EN CAS Find my …

As the worldwide prevalence of chronic liver diseases is high and continuing to increase,
there is an urgent need for treatment to prevent cirrhosis‐related morbidity and mortality …

There is a requirement for efficacious and safe medicines to treat diseases with high unmet
need. The resurgence in αv‐RGD integrin inhibitor drug discovery is poised to contribute to …

A novel series of β-lactam derivatives that was designed and synthesized to target RGD-
binding and leukocyte integrins is reported. The compound library was evaluated by …

A series of 3-aryl (pyrrolidin-1-yl) butanoic acids were synthesized using a
diastereoselective route, via a rhodium catalyzed asymmetric 1, 4-addition of arylboronic …

Alterations in integrin expression and function promote tumour growth, invasion, metastasis
and neoangiogenesis. Head and neck cancers are highly vascular tumours with a tendency …

We consider lead discovery as active search in a space of labelled graphs. In particular, we
extend our recent data‐driven adaptive Markov chain approach, and evaluate it on a …

The αvβ6 integrin has been identified as a target for the treatment of fibrotic diseases, based
on the role it has in activating TGF-β1, a protein implicated in the pathogenesis of fibrosis …

β-Amino acids are being increasingly used in the design of bioactive ligands and more
recently in the generation of novel biomaterials. Peptides containing either individual β …

For the first time a solvent-reagent guide has been developed with a view to providing
greener synthetic conditions for the preparation of thioesters. A number of solvents and …