Lung transplantation is the optimal treatment for selected patients with end-stage chronic
lung diseases. However, chronic lung allograft dysfunction remains the leading obstacle to …

Chronic lung allograft dysfunction (CLAD) remains the major barrier to long‐term survival
after lung transplantation and improved insight into its underlying immunological …

Pathways regulating lung alloimmune responses differ from most other solid organs and
remain poorly explored. Based on our recent work identifying the unique role of eosinophils …

Background Chronic lung allograft dysfunction (CLAD) is the leading cause of death among
lung transplant recipients. Eosinophils, effector cells of type 2 immunity, are implicated in the …

Background Growing evidence suggest that type 2 immune effectors play a role in solid
organ transplantation. The aim of this study was to evaluate the impact of blood count …

Eosinophils are a critical type of immune cell and central players in type 2 immunity. Existing
literature suggests that eosinophils also can play a role in host antiviral responses, typically …

Acute mixed cellular and antibody-mediated rejection (MR) has an estimated prevalence of
7.8%. However, knowledge of MR immune pathogenesis in cardiac graft rejection remains …

Achieving adequate immunosuppression for lung transplant recipients in the first year after
lung transplantation is a key challenge. Prophylaxis of allograft rejection must be balanced …

Background. During solid organ transplantation, donor leukocytes, including myeloid cells,
are transferred within the organ to the recipient. Both tolerogenic and alloreactive roles have …

The liver, the largest internal organ in the human body, is crucial in maintaining health and
vitality. Acute liver injury (ALI) is a condition characterised by the death of hepatocytes due to …