3D bioprinted cancer models: from basic biology to drug development
Effort invested in the development of new drugs often fails to be translated into meaningful
clinical benefits for patients with cancer. The development of more effective anticancer …
clinical benefits for patients with cancer. The development of more effective anticancer …
Bioprinting methods for fabricating in vitro tubular blood vessel models
Dysfunctional blood vessels are implicated in various diseases, including cardiovascular
diseases, neurodegenerative diseases, and cancer. Several studies have attempted to …
diseases, neurodegenerative diseases, and cancer. Several studies have attempted to …
3D bioprinted multilayered cerebrovascular conduits to study cancer extravasation mechanism related with vascular geometry
Cerebral vessels are composed of highly complex structures that facilitate blood perfusion
necessary for meeting the high energy demands of the brain. Their geometrical complexities …
necessary for meeting the high energy demands of the brain. Their geometrical complexities …
Blood‐lymphatic integrated system with heterogeneous melanoma spheroids via in‐bath three‐dimensional bioprinting for modelling of combinational targeted …
Although metastatic melanoma can be managed with chemotherapy, its heterogeneity and
resistance to therapy remain poorly understood. In addition to the spread of melanoma in the …
resistance to therapy remain poorly understood. In addition to the spread of melanoma in the …
3D biofabrication of diseased human skin models in vitro
Human skin is an organ located in the outermost part of the body; thus, it frequently exhibits
visible signs of physiological health. Ethical concerns and genetic differences in …
visible signs of physiological health. Ethical concerns and genetic differences in …
Decellularized ECM hydrogels: prior use considerations, applications, and opportunities in tissue engineering and biofabrication
Tissue development, wound healing, pathogenesis, regeneration, and homeostasis rely
upon coordinated and dynamic spatial and temporal remodeling of extracellular matrix …
upon coordinated and dynamic spatial and temporal remodeling of extracellular matrix …
Vascularized lung cancer model for evaluating the promoted transport of anticancer drugs and immune cells in an engineered tumor microenvironment
D Kim, KS Hwang, EU Seo, S Seo… - Advanced …, 2022 - Wiley Online Library
The tumor microenvironment (TME) is the environment around the tumor, including blood
vessels, immune cells, fibroblasts, signaling molecules, and the extracellular matrix (ECM) …
vessels, immune cells, fibroblasts, signaling molecules, and the extracellular matrix (ECM) …
Advances in 3D bioprinting for cancer biology and precision medicine: From matrix design to application
MS Jung, S Ghamrawi, EY Du… - Advanced …, 2022 - Wiley Online Library
The tumor microenvironment is highly complex owing to its heterogeneous composition and
dynamic nature. This makes tumors difficult to replicate using traditional 2D cell culture …
dynamic nature. This makes tumors difficult to replicate using traditional 2D cell culture …
Triculture model of in vitro BBB and its application to study BBB‐associated chemosensitivity and drug delivery in glioblastoma
Physiologically, brain tumors interact with surrounding vascular and glial cells, and change
their responses to survive in brain tissue‐specific microenvironments. A major difficulty in …
their responses to survive in brain tissue‐specific microenvironments. A major difficulty in …
3D printing of pharmaceutical application: drug screening and drug delivery
Advances in three-dimensional (3D) printing techniques and the development of tailored
biomaterials have facilitated the precise fabrication of biological components and complex …
biomaterials have facilitated the precise fabrication of biological components and complex …