Despite the efforts that bioengineers have exerted in designing and constructing biological
processes that function according to a predetermined set of rules, their operation remains …

Synthetic gene circuits are designed to program new biological behaviour, dynamics and
logic control. For all but the simplest synthetic phenotypes, this requires a structured …

Over the past decade, synthetic biology has emerged as an engineering discipline for
biological systems. Compared with other substrates, biology poses a unique set of …

Synthetic biology may be viewed as an effort to establish, formalize, and develop an
engineering discipline in the context of biological systems. The ability to tune the properties …

A challenge in biology is to understand how complex molecular networks in the cell execute
sophisticated regulatory functions. Here we explore the idea that there are common and …

Advances in synthetic biology now allow for the reprogramming of microorganisms to
execute specific tasks. Here, we describe the development of an engineered strain of E. coli …

Cadmium (Cd) is carcinogenic to humans and can accumulate in the liver, kidneys, and
bones. There is widespread presence of cadmium in the environment as a consequence of …

Synthetic biology promises to revolutionize biotechnology by providing the means to
reengineer and reprogram cellular regulatory mechanisms. However, synthetic gene circuits …

Unlike their natural counterparts, synthetic genetic circuits are usually fragile in the face of
environmental perturbations and genetic mutations. Several theoretical robust genetic …

Precise control of gene expression is critical for biological research and biotechnology.
However, transient plasmid transfections in mammalian cells produce a wide distribution of …