Contextualizing context for synthetic biology–identifying causes of failure of synthetic biological systems
S Cardinale, AP Arkin - Biotechnology journal, 2012 - Wiley Online Library
Despite the efforts that bioengineers have exerted in designing and constructing biological
processes that function according to a predetermined set of rules, their operation remains …
processes that function according to a predetermined set of rules, their operation remains …
Foundations for the design and implementation of synthetic genetic circuits
Synthetic gene circuits are designed to program new biological behaviour, dynamics and
logic control. For all but the simplest synthetic phenotypes, this requires a structured …
logic control. For all but the simplest synthetic phenotypes, this requires a structured …
Synthetic biology: an emerging engineering discipline
AA Cheng, TK Lu - Annual review of biomedical engineering, 2012 - annualreviews.org
Over the past decade, synthetic biology has emerged as an engineering discipline for
biological systems. Compared with other substrates, biology poses a unique set of …
biological systems. Compared with other substrates, biology poses a unique set of …
Tuning response curves for synthetic biology
J Ang, E Harris, BJ Hussey, R Kil… - ACS synthetic …, 2013 - ACS Publications
Synthetic biology may be viewed as an effort to establish, formalize, and develop an
engineering discipline in the context of biological systems. The ability to tune the properties …
engineering discipline in the context of biological systems. The ability to tune the properties …
[HTML][HTML] Design principles of regulatory networks: searching for the molecular algorithms of the cell
WA Lim, CM Lee, C Tang - Molecular cell, 2013 - cell.com
A challenge in biology is to understand how complex molecular networks in the cell execute
sophisticated regulatory functions. Here we explore the idea that there are common and …
sophisticated regulatory functions. Here we explore the idea that there are common and …
Engineered E. coli That Detect and Respond to Gut Inflammation through Nitric Oxide Sensing
EJ Archer, AB Robinson, GM Süel - ACS synthetic biology, 2012 - ACS Publications
Advances in synthetic biology now allow for the reprogramming of microorganisms to
execute specific tasks. Here, we describe the development of an engineered strain of E. coli …
execute specific tasks. Here, we describe the development of an engineered strain of E. coli …
[HTML][HTML] Detection of bioavailable cadmium by double-color fluorescence based on a dual-sensing bioreporter system
C Hui, Y Guo, J Wu, L Liu, X Yang, X Guo… - Frontiers in …, 2021 - frontiersin.org
Cadmium (Cd) is carcinogenic to humans and can accumulate in the liver, kidneys, and
bones. There is widespread presence of cadmium in the environment as a consequence of …
bones. There is widespread presence of cadmium in the environment as a consequence of …
Engineered temperature compensation in a synthetic genetic clock
F Hussain, C Gupta, AJ Hirning, W Ott… - Proceedings of the …, 2014 - National Acad Sciences
Synthetic biology promises to revolutionize biotechnology by providing the means to
reengineer and reprogram cellular regulatory mechanisms. However, synthetic gene circuits …
reengineer and reprogram cellular regulatory mechanisms. However, synthetic gene circuits …
Synthetic robust perfect adaptation achieved by negative feedback coupling with linear weak positive feedback
Z Sun, W Wei, M Zhang, W Shi, Y Zong… - Nucleic Acids …, 2022 - academic.oup.com
Unlike their natural counterparts, synthetic genetic circuits are usually fragile in the face of
environmental perturbations and genetic mutations. Several theoretical robust genetic …
environmental perturbations and genetic mutations. Several theoretical robust genetic …
[HTML][HTML] A synthetic circuit for buffering gene dosage variation between individual mammalian cells
Precise control of gene expression is critical for biological research and biotechnology.
However, transient plasmid transfections in mammalian cells produce a wide distribution of …
However, transient plasmid transfections in mammalian cells produce a wide distribution of …