The incidence of depression and anxiety is amplified by obesity. Mounting evidence reveals
that the psychiatric consequences of obesity stem from poor diet, inactivity, and visceral …

Depression is a common and serious disorder, characterized by symptoms like anhedonia,
lack of energy, sad mood, low appetite, and sleep disturbances. This disease is very …

Bipolar disorders (BD) represent a severe leading disabling mental condition worldwide
characterized by episodic and often progressive mood fluctuations with manic and …

Regulation of emotions is generally associated exclusively with the brain. However, there is
evidence that peripheral systems are also involved in mood, stress vulnerability vs …

Highlights•Chronic stress, depression and inflammation have been consistently
linked.•Stress-induced inflammatory states can contribute to treatment resistance.•Ketamine …

Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with a high
individual and societal burden. While not all patients display overt markers of elevated …

There is growing interest in the role that the intestinal microbiota and the related
autoimmune processes may have in the genesis and presentation of some psychiatric …

Growing evidence suggests that a dysregulation of the kynurenine pathway (KP) occurs in
bipolar disorder (BD). This systematic review and meta-analysis aimed at assessing the …

Background: Ketamine is a novel rapid-acting antidepressant with high efficacy in treatment-
resistant patients. Its exact therapeutic mechanisms of action are unclear; however, in recent …

Abstract (R, S)-ketamine (ketamine) and its enantiomer (S)-ketamine (esketamine) can
produce rapid and substantial antidepressant effects. However, individual response to …