Association of oxidative stress on pregnancy
K Toboła-Wróbel, M Pietryga… - Oxidative medicine …, 2020 - Wiley Online Library
The pathophysiological mechanism underlying pregnancy complications such as congenital
malformations, miscarriage, preeclampsia, or fetal growth restriction is not entirely known …
malformations, miscarriage, preeclampsia, or fetal growth restriction is not entirely known …
[HTML][HTML] Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets
A Izzo, N Mollo, M Nitti, S Paladino, G Calì… - Molecular …, 2018 - Springer
Abstract Trisomy of chromosome 21 (TS21) is the most common autosomal aneuploidy
compatible with postnatal survival with a prevalence of 1 in 700 newborns. Its phenotype is …
compatible with postnatal survival with a prevalence of 1 in 700 newborns. Its phenotype is …
Lysosomal dysfunction in Down syndrome is APP-dependent and mediated by APP-βCTF (C99)
Lysosomal failure underlies pathogenesis of numerous congenital neurodegenerative
disorders and is an early and progressive feature of Alzheimer's disease (AD) pathogenesis …
disorders and is an early and progressive feature of Alzheimer's disease (AD) pathogenesis …
[HTML][HTML] Down syndrome is a metabolic disease: altered insulin signaling mediates peripheral and brain dysfunctions
M Dierssen, M Fructuoso… - Frontiers in …, 2020 - frontiersin.org
Down syndrome (DS) is the most frequent chromosomal abnormality that causes intellectual
disability, resulting from the presence of an extra complete or segment of chromosome 21 …
disability, resulting from the presence of an extra complete or segment of chromosome 21 …
[HTML][HTML] The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down …
Mitochondrial dysfunctions critically impair nervous system development and are potentially
involved in the pathogenesis of various neurodevelopmental disorders, including Down …
involved in the pathogenesis of various neurodevelopmental disorders, including Down …
Down syndrome: Neurobiological alterations and therapeutic targets
Down syndrome (DS) is a genetic disease that occurs due to an aneuploidy of human
chromosome 21. Trisomy of chromosome 21 is a primary genetic cause of developmental …
chromosome 21. Trisomy of chromosome 21 is a primary genetic cause of developmental …
[HTML][HTML] Metformin in therapeutic applications in human diseases: Its mechanism of action and clinical study
Y Du, YJ Zhu, YX Zhou, J Ding, JY Liu - Molecular Biomedicine, 2022 - Springer
Metformin, a biguanide drug, is the most commonly used first-line medication for type 2
diabetes mellites due to its outstanding glucose-lowering ability. After oral administration of …
diabetes mellites due to its outstanding glucose-lowering ability. After oral administration of …
Mitochondria as pharmacological targets in Down syndrome
Mitochondria play a pivotal role in cellular energy-generating processes and are considered
master regulators of cell life and death fate. Mitochondrial function integrates signalling …
master regulators of cell life and death fate. Mitochondrial function integrates signalling …
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome
E Lana-Elola, R Aoidi, M Llorian, D Gibbins… - Science translational …, 2024 - science.org
Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21). DS is a gene
dosage disorder that results in multiple phenotypes including congenital heart defects. This …
dosage disorder that results in multiple phenotypes including congenital heart defects. This …
Metformin restores the mitochondrial network and reverses mitochondrial dysfunction in Down syndrome cells
A Izzo, M Nitti, N Mollo, S Paladino… - Human molecular …, 2017 - academic.oup.com
Alterations in mitochondrial activity and morphology have been demonstrated in human
cells and tissues from individuals with Down syndrome (DS), as well as in DS mouse …
cells and tissues from individuals with Down syndrome (DS), as well as in DS mouse …