Normal eating behaviour is coordinated by the tightly regulated balance between intestinal
and extra-intestinal homeostatic and hedonic mechanisms. By contrast, food addiction is a …

Obesity results from an imbalance between energy intake and expenditure, and many
studies have aimed to determine why obese individuals continue to (over) consume food …

Objective Parkinson disease is characterized by motor and nonmotor symptoms, reduced
striatal dopamine signaling, and loss of dopamine neurons in the substantia nigra. It is now …

Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons.
Exercise has been reported to slow the clinical progression of PD. We evaluated the …

Purpose Emerging work indicates divergence in the neurobiologies of binge-eating disorder
(BED) and obesity despite their frequent co-occurrence. This review highlights specific …

Feeding induces dopamine release in the striatum, and a dysfunction of the dopaminergic
reward system can lead to overeating, and obesity. Studies have reported inconsistent …

There is significant evidence linking a 'reward deficiency syndrome'(RDS), comprising
decreased availability of striatal dopamine D2-like receptors (DD2lR) and addiction-like …

Dopamine is a neurotransmitter that plays a crucial role in adaptive behavior. A wealth of
studies suggests obesity-related alterations in the central dopamine system. The most direct …

Background Neuroimaging studies have identified obesity‐related differences in the brain's
resting state activity. An imbalance between homeostatic and reward aspects of ingestive …

This was a first-in-human study of the PET radiotracer 11C-LSN3172176 for the muscarinic
acetylcholine receptor subtype M1. The objectives of the study were to determine the …