Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …

Adipose tissue, best known for its role in fat storage, can also suppress weight gain and
metabolic disease through the action of specialized, heat-producing adipocytes. Brown …

Accumulation of excess white adipose tissue (WAT) has deleterious consequences for
metabolic health. The activation of brown adipose tissue (BAT), the primary organ for heat …

Multiple biologically active components of human milk support infant growth, health and
development. Milk provides a wide spectrum of mammary epithelial cell-derived …

One of the most promising areas in the therapeutics for metabolic diseases centers around
activation of the pathways of energy expenditure. Brown adipose tissue is a particularly …

The imbalance between energy intake and expenditure is the underlying cause of the
current obesity and diabetes pandemics. Central to these pathologies is the fat depot: white …

White adipocytes store excess energy in the form of triglycerides, whereas brown and beige
adipocytes dissipate energy in the form of heat. This thermogenic function relies on the …

Brown adipose tissue dissipates energy through heat and functions as a defense against
cold and obesity. PPARγ ligands have been shown to induce the browning of white …

Although it is well established that physical activity increases mitochondrial content in
muscle, the molecular mechanisms underlying this process have only recently been …

Brown adipose tissue (BAT) dissipates chemical energy and generates heat to protect
animals from cold and obesity. Rodents possess two types of UCP-1 positive brown …