Abstract Design and synthesis of efficient drug delivery systems are of vital importance for
medicine and healthcare. Nanocarrier-based drug delivery systems, in particular …

Protein and peptide drugs hold great promise as therapeutic agents. However, many are
degraded by proteolytic enzymes, can be rapidly cleared by the kidneys, generate …

Once a rarely used subset of medical treatments, protein therapeutics have increased
dramatically in number and frequency of use since the introduction of the first recombinant …

Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

PEGylation is one of the most successful strategies to improve the delivery of therapeutic
molecules such as proteins, macromolecular carriers, small drugs, oligonucleotides, and …

The use of liposomal carriers and the modification of therapeutic molecules through the
attachment of poly (ethylene glycol)[PEG] moieties ('pegylation') are the most common …

Abstract l-Asparaginase (EC3. 5.1. 1) is an enzyme, which is used for treatment of acute
lymphoblastic leukaemia (ALL) and other related blood cancers from a long time. This …

The potential of peptide and protein anticancer agents has yet to be realized owing to the
many unresolved problems concerning their delivery to the site of a tumor and into tumor …

This article comprises detailed information about L-asparaginase, encompassing topics
such as microbial and plant sources of L-asparaginase, treatment with L-asparaginase …

Pegylation, generally described as the molecular attachment of polyethylene glycols (PEGs)
with different molecular weights to active drug molecules or surface treatment of drug …