Recent advances in models, mechanisms, biomarkers, and interventions in cisplatin-induced acute kidney injury

SJ Holditch, CN Brown, AM Lombardi… - International journal of …, 2019 - mdpi.com
Cisplatin is a widely used chemotherapeutic agent used to treat solid tumours, such as
ovarian, head and neck, and testicular germ cell. A known complication of cisplatin …

Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity

V Volarevic, B Djokovic, MG Jankovic… - Journal of biomedical …, 2019 - Springer
Background Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective
chemotherapeutic agents. However, its clinical use is limited due to the severe side effects …

Bee venom: an updating review of its bioactive molecules and its health applications

M Carpena, B Nuñez-Estevez, A Soria-Lopez… - Nutrients, 2020 - mdpi.com
Bee venom (BV) is usually associated with pain since, when humans are stung by bees,
local inflammation and even an allergic reaction can be produced. BV has been traditionally …

[HTML][HTML] Pharmacological properties and therapeutic potential of honey bee venom

A Ullah, FM Aldakheel, SI Anjum, G Raza… - Saudi Pharmaceutical …, 2023 - Elsevier
Honey bee venom (BV) is a valuable product, and has a wide range of biological effects,
and its use is rapidly increasing in apitherapy. Therefore, the current study, we reviewed the …

Impact of bee venom enzymes on diseases and immune responses

MS Hossen, UM Shapla, SH Gan, MI Khalil - Molecules, 2016 - mdpi.com
Bee venom (BV) is used to treat many diseases and exhibits anti-inflammatory, anti-
bacterial, antimutagenic, radioprotective, anti-nociceptive immunity promoting, hepatocyte …

[HTML][HTML] MiR-155 deficiency protects renal tubular epithelial cells from telomeric and genomic DNA damage in cisplatin-induced acute kidney injury

Q Yin, YJ Zhao, WJ Ni, TT Tang, Y Wang, JY Cao… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Cisplatin nephrotoxicity is an important cause of acute kidney injury (AKI), limiting
cisplatin application in cancer therapy. Growing evidence has suggested that genome …

Bee Venom Phospholipase A2: Yesterday's Enemy Becomes Today's Friend

G Lee, H Bae - Toxins, 2016 - mdpi.com
Bee venom therapy has been used to treat immune-related diseases such as arthritis for a
long time. Recently, it has revealed that group III secretory phospholipase A2 from bee …

Neuroprotective effects of bee venom phospholipase A2 in the 3xTg AD mouse model of Alzheimer's disease

M Ye, HS Chung, C Lee, MS Yoon, AR Yu… - Journal of …, 2016 - Springer
Background Alzheimer's disease (AD) is a severe neuroinflammatory disease. CD4+
Foxp3+ regulatory T cells (Tregs) modulate various inflammatory diseases via suppressing …

Dexmedetomidine protects against cisplatin-induced acute kidney injury in mice through regulating apoptosis and inflammation

H Liang, HZ Liu, HB Wang, JY Zhong, CX Yang… - Inflammation …, 2017 - Springer
Objective and design Cisplatin-based chemotherapy has been widely used in the
perioperative period of cancer surgery, which exacerbates the risk of renal injury. In this …

Regulatory T cells in acute and chronic kidney diseases

R Sharma, GR Kinsey - American Journal of Physiology …, 2018 - journals.physiology.org
Foxp3-expressing CD4+ regulatory T cells (Tregs) make up one subset of the helper T cells
(Th) and are one of the major mechanisms of peripheral tolerance. Tregs prevent abnormal …