Targeting the tumor stroma for cancer therapy
M Xu, T Zhang, R Xia, Y Wei, X Wei - Molecular Cancer, 2022 - Springer
Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …
Endothelial cell metabolism
G Eelen, P de Zeeuw, L Treps, U Harjes… - Physiological …, 2018 - journals.physiology.org
Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …
active players in the formation of new blood vessels (angiogenesis) both in health and (life …
Tumor microenvironment and therapeutic response
T Wu, Y Dai - Cancer letters, 2017 - Elsevier
The tumor microenvironment significantly influences therapeutic response and clinical
outcome. Microenvironment-mediated drug resistance can be induced by soluble factors …
outcome. Microenvironment-mediated drug resistance can be induced by soluble factors …
Cellular and molecular players in the tumor microenvironment of renal cell carcinoma
F Lasorsa, M Rutigliano, M Milella, M Ferro… - Journal of Clinical …, 2023 - mdpi.com
Globally, clear-cell renal cell carcinoma (ccRCC) represents the most prevalent type of
kidney cancer. Surgery plays a key role in the treatment of this cancer, although one third of …
kidney cancer. Surgery plays a key role in the treatment of this cancer, although one third of …
Three-dimensional culture system of cancer cells combined with biomaterials for drug screening
T Nii, K Makino, Y Tabata - Cancers, 2020 - mdpi.com
Simple Summary For the research and development of drug discovery, it is of prime
importance to construct the three-dimensional (3D) tissue models in vitro. To this end, the …
importance to construct the three-dimensional (3D) tissue models in vitro. To this end, the …
Targeting angiogenesis in breast cancer: current evidence and future perspectives of novel anti-angiogenic approaches
NM Ayoub, SK Jaradat, KM Al-Shami… - Frontiers in …, 2022 - frontiersin.org
Angiogenesis is a vital process for the growth and dissemination of solid cancers. Numerous
molecular pathways are known to drive angiogenic switch in cancer cells promoting the …
molecular pathways are known to drive angiogenic switch in cancer cells promoting the …
Determinants of resistance to VEGF-TKI and immune checkpoint inhibitors in metastatic renal cell carcinoma
R Sharma, E Kadife, M Myers, G Kannourakis… - Journal of Experimental …, 2021 - Springer
Vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs) have been the
mainstay of treatment for patients with advanced renal cell carcinoma (RCC). Despite its …
mainstay of treatment for patients with advanced renal cell carcinoma (RCC). Despite its …
Immunotherapy in renal cell carcinoma: the future is now
A Deleuze, J Saout, F Dugay, B Peyronnet… - International Journal of …, 2020 - mdpi.com
Renal cell carcinoma is the third type of urologic cancer and has a poor prognosis with 30%
of metastatic patients at diagnosis. The antiangiogenics and targeted immunotherapies led …
of metastatic patients at diagnosis. The antiangiogenics and targeted immunotherapies led …
Tumor endothelial cells accelerate tumor metastasis
N Maishi, K Hida - Cancer science, 2017 - Wiley Online Library
Tumor metastasis is the main cause of cancer‐related death. Understanding the molecular
mechanisms underlying tumor metastasis is crucial to control this fatal disease. Several …
mechanisms underlying tumor metastasis is crucial to control this fatal disease. Several …
Tumor endothelial cells (TECs) as potential immune directors of the tumor microenvironment–new findings and future perspectives
L Nagl, L Horvath, A Pircher, D Wolf - Frontiers in cell and …, 2020 - frontiersin.org
The tumor microenvironment (TME) plays a central role in cancer development and
progression. It represents a complex network of cancer cell (sub-) clones and a variety of …
progression. It represents a complex network of cancer cell (sub-) clones and a variety of …