Proteogenomic data and resources for pan-cancer analysis
Summary The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium
(CPTAC) investigates tumors from a proteogenomic perspective, creating rich multi-omics …
(CPTAC) investigates tumors from a proteogenomic perspective, creating rich multi-omics …
Identification of splice variants and isoforms in transcriptomics and proteomics
T Su, MAR Hollas, RT Fellers… - Annual review of …, 2023 - annualreviews.org
Alternative splicing is pivotal to the regulation of gene expression and protein diversity in
eukaryotic cells. The detection of alternative splicing events requires specific omics …
eukaryotic cells. The detection of alternative splicing events requires specific omics …
Advances in nanopore direct RNA sequencing
Nanopore direct RNA sequencing (DRS) reads continuous native RNA strands. Early
adopters have used this technology to document nucleotide modifications and 3 …
adopters have used this technology to document nucleotide modifications and 3 …
Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapy
Immunotherapy has emerged as a crucial strategy to combat cancer by “reprogramming” a
patient's own immune system. Although immunotherapy is typically reserved for patients with …
patient's own immune system. Although immunotherapy is typically reserved for patients with …
The variables on RNA molecules: concert or cacophony? Answers in long-read sequencing
Long-read sequencing has become a widely employed technology that enables a
comprehensive view of RNA transcripts. Here, we discuss the importance of long-read …
comprehensive view of RNA transcripts. Here, we discuss the importance of long-read …
Bridging the splicing gap in human genetics with long-read RNA sequencing: finding the protein isoform drivers of disease
Aberrant splicing underlies many human diseases, including cancer, cardiovascular
diseases and neurological disorders. Genome-wide mapping of splicing quantitative trait …
diseases and neurological disorders. Genome-wide mapping of splicing quantitative trait …
A roadmap for the functional annotation of protein families: a community perspective
Over the last 25 years, biology has entered the genomic era and is becoming a science of
'big data'. Most interpretations of genomic analyses rely on accurate functional annotations …
'big data'. Most interpretations of genomic analyses rely on accurate functional annotations …
Proteogenomics reveals sex-biased aging genes and coordinated splicing in cardiac aging
The risks of heart diseases are significantly modulated by age and sex, but how these
factors influence baseline cardiac gene expression remains incompletely understood. Here …
factors influence baseline cardiac gene expression remains incompletely understood. Here …
Synergistic antitumor effects of compound-composed optimal formula from Aidi injection on hepatocellular carcinoma and colorectal cancer
P An, D Lu, L Zhang, H Lan, H Yang, G Ge, W Liu… - Phytomedicine, 2022 - Elsevier
Abstract Background Traditional Chinese medicine formula (TCMF) possesses unique
advantages in the prevention and treatment of malignant tumors such as hepatocellular …
advantages in the prevention and treatment of malignant tumors such as hepatocellular …
A critical evaluation of ultrasensitive single-cell proteomics strategies
MR Nalehua, J Zaia - Analytical and Bioanalytical Chemistry, 2024 - Springer
Success of mass spectrometry characterization of the proteome of single cells allows us to
gain a greater understanding than afforded by transcriptomics alone but requires clear …
gain a greater understanding than afforded by transcriptomics alone but requires clear …