P2X7 receptor: an emerging target in Alzheimer's disease

Q Huang, J Ying, W Yu, Y Dong, H Xiong… - Molecular …, 2024 - Springer
Alzheimer's disease (AD) is a major cause of age-related dementia, which is becoming a
global health crisis. However, the pathogenesis and etiology of AD are still not fully …

Recommended tool compounds and drugs for blocking P2X and P2Y receptors

CE Müller, V Namasivayam - Purinergic signalling, 2021 - Springer
This review article presents a collection of tool compounds that selectively block and are
recommended for studying P2Y and P2X receptor subtypes, investigating their roles in …

Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson's Disease

FQ Gonçalves, FC Matheus, HB Silva, JI Real… - Molecular …, 2023 - Springer
Extracellular ATP can be a danger signal, but its role in striatal circuits afflicted in
Parkinson's disease (PD) is unclear and was now investigated. ATP was particularly …

A current review on P2X7 receptor antagonist patents in the treatment of neuroinflammatory disorders: a patent review on antagonists

S Soni, MS Lukhey, BS Thawkar… - Naunyn-Schmiedeberg's …, 2024 - Springer
Chronic inflammation is defined by an activated microglial state linked to all neurological
disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral …