Screening and testing for endocrine disruption in fish—biomarkers as “signposts,” not “traffic lights,” in risk assessment

TH Hutchinson, GT Ankley, H Segner… - Environmental health …, 2006 - ehp.niehs.nih.gov
Biomarkers are currently best used as mechanistic “signposts” rather than as “traffic lights” in
the environmental risk assessment of endocrine-disrupting chemicals (EDCs). In field …

Predicted‐no‐effect concentrations for the steroid estrogens estrone, 17β‐estradiol, estriol, and 17α‐ethinylestradiol

DJ Caldwell, F Mastrocco, PD Anderson… - Environmental …, 2012 - Wiley Online Library
The authors derive predicted‐no‐effect concentrations (PNECs) for the steroid estrogens
(estrone [E1], 17β‐estradiol [E2], estriol [E3], and 17α‐ethinylestradiol [EE2]) appropriate for …

Transgenic fish systems and their application in ecotoxicology

O Lee, JM Green, CR Tyler - Critical reviews in toxicology, 2015 - Taylor & Francis
The use of transgenics in fish is a relatively recent development for advancing
understanding of genetic mechanisms and developmental processes, improving …

Mixtures of estrogenic contaminants in bile of fish exposed to wastewater treatment works effluents

R Gibson, MD Smith, CJ Spary, CR Tyler… - … science & technology, 2005 - ACS Publications
Most effluents from wastewater treatment works (WwTWs) contain estrogenic chemicals that
include steroidal estrogens and xenoestrogens. We investigated the nature of mixtures of …

Using NMR metabolomics to identify responses of an environmental estrogen in blood plasma of fish

LM Samuelsson, L Förlin, G Karlsson… - Aquatic toxicology, 2006 - Elsevier
Nuclear magnetic resonance (NMR) based metabolomics in combination with multivariate
data analysis may become valuable tools to study environmental effects of pharmaceuticals …

Pharmaceutical industry effluent diluted 1: 500 affects global gene expression, cytochrome P450 1A activity, and plasma phosphate in fish

L Gunnarsson, E Kristiansson… - Environmental …, 2009 - Wiley Online Library
Abstract Patancheru, near Hyderabad, India, is a major production site for the global bulk
drug market. Approximately 90 manufacturers send their wastewater to a common treatment …

Gonadal transcriptome responses and physiological consequences of exposure to oestrogen in breeding zebrafish (Danio rerio)

EM Santos, GC Paull, KJW Van Look, VL Workman… - Aquatic toxicology, 2007 - Elsevier
Environmental oestrogens are widespread in the aquatic environment and cause alterations
in sexual development and function in vertebrates. The molecular pathways underpinning …

Accounting for Differences in Estrogenic Responses in Rainbow Trout (Oncorhynchus mykiss:  Salmonidae) and Roach (Rutilus rutilus:  Cyprinidae) Exposed to …

CR Tyler, C Spary, R Gibson, EM Santos… - Environmental …, 2005 - ACS Publications
Effluents from wastewater treatment works (WwTWs) contain estrogenic substances that
induce feminizing effects in fish, including vitellogenin (VTG) synthesis and gonadal …

17-β-Estradiol: Significant reduction of its toxicity in water treated by photocatalysis

L Orozco-Hernández, LM Gómez-Oliván… - Science of The Total …, 2019 - Elsevier
The aim of this study was to assess the efficiency of photocatalysis by TiO 2 on the removal
of 17-β-estradiol (E2)(at environmentally relevant concentrations) and the toxicity caused by …

Modeling effects of mixtures of endocrine disrupting chemicals at the river catchment scale

JP Sumpter, AC Johnson, RJ Williams… - … science & technology, 2006 - ACS Publications
For endocrine disrupting chemicals in the environment, concerns arise primarily from the
effects that may be induced in wildlife. A well studied example is estrogenic chemicals in the …