Bidirectional somatic cell–oocyte signaling is essential to create a changing intrafollicular
microenvironment that controls primordial follicle growth into a cohort of growing follicles …

Recent studies challenge the previous view that apoptosis within the granulosa cells of the
maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of …

Luteinizing hormone (LH) in synergy with follicle stimulating hormone (FSH) stimulates
normal follicular growth and ovulation. FSH is frequently used in assisted reproductive …

STUDY QUESTION How does the efficacy and safety of a fixed-ratio combination of
recombinant human FSH plus recombinant human LH (follitropin alfa plus lutropin alfa; r …

Purpose To evaluate the relationship between apoptosis of granulosa cells in women with
normal ovarian reserve versus diminished ovarian reserve, and relate that to follicular fluid …

OBJECTIVE: To analyze the impact of LH administration on cycle outcome in ovarian
stimulation with GnRH antagonists. DESIGN: Randomized, open-label, controlled trial …

Previous studies indicate that stress damages oocytes with increased secretion of
glucorticoids. However, although injection of female mice with cortisol decreased oocyte …

A serine/threonine-specific protein kinase B (PKB), also known as Akt, is a key factor in the
phosphoinositide 3-kinase (PI3K)/Akt signaling pathway that regulates cell survival …

The vertebrate ovary is an extremely dynamic organ in which excessive or defective follicles
are rapidly and effectively eliminated early in ontogeny and thereafter continuously …

BACKGROUND Several protocols for the isolation of luteinized granulosa cells (LGCs)
contained in follicular fluid have been described but no previously published study has …