Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines
L Guo, S Lin, Z Chen, Y Cao, B He, G Lu - Signal Transduction and …, 2023 - nature.com
The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused devastating impacts …
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused devastating impacts …
In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms
S Cankat, MU Demael, L Swadling - Cellular & molecular immunology, 2024 - nature.com
Members of the coronaviridae family are endemic to human populations and have caused
several epidemics and pandemics in recent history. In this review, we will discuss the …
several epidemics and pandemics in recent history. In this review, we will discuss the …
Mapping immunodominant sites on the MERS-CoV spike glycoprotein targeted by infection-elicited antibodies in humans
A Addetia, C Stewart, AJ Seo, KR Sprouse, AY Asiri… - Cell Reports, 2024 - cell.com
Middle East respiratory syndrome coronavirus (MERS-CoV) first emerged in 2012 and
causes human infections in endemic regions. Vaccines and therapeutics in development …
causes human infections in endemic regions. Vaccines and therapeutics in development …
Broad protection against clade 1 sarbecoviruses after a single immunization with cocktail spike-protein-nanoparticle vaccine
PJ Halfmann, K Loeffler, A Duffy, M Kuroda… - Nature …, 2024 - nature.com
The 2002 SARS outbreak, the 2019 emergence of COVID-19, and the continuing evolution
of immune-evading SARS-CoV-2 variants together highlight the need for a broadly …
of immune-evading SARS-CoV-2 variants together highlight the need for a broadly …
The S2 subunit of spike encodes diverse targets for functional antibody responses to SARS-CoV-2
J Guenthoer, ME Garrett, M Lilly, DM Depierreux… - PLoS …, 2024 - journals.plos.org
The SARS-CoV-2 virus responsible for the COVID-19 global pandemic has exhibited a
striking capacity for viral evolution that drives continued evasion from vaccine and infection …
striking capacity for viral evolution that drives continued evasion from vaccine and infection …
Discovery and Characterization of a Pan-betacoronavirus S2-binding antibody
The continued emergence of deadly human coronaviruses from animal reservoirs highlights
the need for pan-coronavirus interventions for effective pandemic preparedness. Here, using …
the need for pan-coronavirus interventions for effective pandemic preparedness. Here, using …
Clinical Utility of SARS-CoV-2 Serological Testing and Defining a Correlate of Protection
Herein, we review established clinical use cases for SARS-CoV-2 antibody measures, which
include diagnosis of recent prior infection, isolating high titer convalescent plasma …
include diagnosis of recent prior infection, isolating high titer convalescent plasma …
Simulation-driven design of stabilized SARS-CoV-2 spike S2 immunogens
The full-length prefusion-stabilized SARS-CoV-2 spike (S) is the principal antigen of COVID-
19 vaccines. Vaccine efficacy has been impacted by emerging variants of concern that …
19 vaccines. Vaccine efficacy has been impacted by emerging variants of concern that …
Immunity to seasonal coronavirus spike proteins does not protect from SARS-CoV-2 challenge in a mouse model but has no detrimental effect on protection mediated …
Seasonal coronaviruses have been circulating widely in the human population for many
years. With increasing age, humans are more likely to have been exposed to these viruses …
years. With increasing age, humans are more likely to have been exposed to these viruses …
[HTML][HTML] Identification of nurse shark VNAR single-domain antibodies targeting the spike S2 subunit of SARS-CoV-2
J Buffington, Z Duan, HJ Kwon, J Hong… - … : official publication of …, 2023 - ncbi.nlm.nih.gov
SARS-CoV-2 is the etiological agent of the COVID-19 pandemic. Antibody-based
therapeutics targeting the spike protein, specifically the S1 subunit or the receptor binding …
therapeutics targeting the spike protein, specifically the S1 subunit or the receptor binding …