[HTML][HTML] Engineering the multiscale complexity of vascular networks
The survival of vertebrate organisms depends on highly regulated delivery of oxygen and
nutrients through vascular networks that pervade nearly all tissues in the body …
nutrients through vascular networks that pervade nearly all tissues in the body …
Challenges and opportunities for the next generation of cardiovascular tissue engineering
Engineered cardiac tissues derived from human induced pluripotent stem cells offer unique
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …
[HTML][HTML] A transcription factor atlas of directed differentiation
Transcription factors (TFs) regulate gene programs, thereby controlling diverse cellular
processes and cell states. To comprehensively understand TFs and the programs they …
processes and cell states. To comprehensively understand TFs and the programs they …
Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine
Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …
now can generate most cells of the human body in the laboratory. PSC-derived …
[HTML][HTML] Cardioids reveal self-organizing principles of human cardiogenesis
P Hofbauer, SM Jahnel, N Papai, M Giesshammer… - Cell, 2021 - cell.com
Organoids capable of forming tissue-like structures have transformed our ability to model
human development and disease. With the notable exception of the human heart, lineage …
human development and disease. With the notable exception of the human heart, lineage …
SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes
Y Li, DM Renner, CE Comar… - Proceedings of the …, 2021 - National Acad Sciences
Coronaviruses are adept at evading host antiviral pathways induced by viral double-
stranded RNA, including interferon (IFN) signaling, oligoadenylate synthetase–ribonuclease …
stranded RNA, including interferon (IFN) signaling, oligoadenylate synthetase–ribonuclease …
Bioprinting: From Tissue and Organ Development to in Vitro Models
Bioprinting techniques have been flourishing in the field of biofabrication with pronounced
and exponential developments in the past years. Novel biomaterial inks used for the …
and exponential developments in the past years. Novel biomaterial inks used for the …
[HTML][HTML] High-throughput screening enhances kidney organoid differentiation from human pluripotent stem cells and enables automated multidimensional …
SM Czerniecki, NM Cruz, JL Harder, R Menon, J Annis… - Cell stem cell, 2018 - cell.com
Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-
throughput screening (HTS), but the complexity of organoid cultures poses a significant …
throughput screening (HTS), but the complexity of organoid cultures poses a significant …
Cardiomyocyte regeneration: a consensus statement
Circulation. 2017; 136: 680–686. DOI: 10.1161/CIRCULATIONAHA. 117.029343 August 15,
2017 681 proliferation. 5 It remains unclear whether this regenerative window exists in large …
2017 681 proliferation. 5 It remains unclear whether this regenerative window exists in large …
Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy
S Marchiano, K Nakamura, H Reinecke, L Neidig… - Cell Stem Cell, 2023 - cell.com
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) offer a promising cell-
based therapy for myocardial infarction. However, the presence of transitory ventricular …
based therapy for myocardial infarction. However, the presence of transitory ventricular …