The lungs are exposed to reactive oxygen species oxygen (ROS) produced as a result of
inhalation of oxygen, as well as smoke and other air pollutants. Cell metabolism and the …

The discovery and application of antibiotics in the common clinical practice has undeniably
been one of the major medical advances in our times. Their use meant a drastic drop in …

Chronic obstructive pulmonary disease (COPD) is characterized by irreversible deterioration
of the airway wall. Cigarette smoking is the major trigger, and in vitro studies showed that …

The airway smooth muscle (ASM) surrounding the airways is dysfunctional in both asthma
and chronic obstructive pulmonary disease (COPD), exhibiting; increased contraction …

Rheumatoid arthritis (RA) often leads to functional disabilities and deformities. MiRNA plays
a vital role in cell pyroptosis. Nevertheless, the function and underlying mechanism of miR …

Proinflammatory cytokines such as TNFα mediate airway inflammation. Previously, we
showed that TNFα increases mitochondrial biogenesis in human ASM (hASM) cells, which is …

Airway inflammation and pro-inflammatory cytokines such as tumor necrosis factor alpha
(TNFα) underlie the pathophysiology of respiratory diseases, including asthma. Previously …

Mitochondria are dynamic membrane-bound organelles in eukaryotic cells. These are
important for the generation of chemical energy needed to power various cellular functions …

Airway hyperresponsiveness (AHR) is a major clinical phenomenon in lung diseases
(asthma, COPD and pulmonary fibrosis) and not only a high-risk factor for perioperative …

Cellular mitochondrial function can be assessed using high-resolution respirometry that
measures the O2 consumption rate (OCR) across a number of cells. However, a direct …