Alcohol is one of the most widely consumed psychoactive drugs globally. Hazardous
drinking, defined by quantity and frequency of consumption, is associated with acute and …

Emotions arise from activations of specialized neuronal populations in several parts of the
cerebral cortex, notably the anterior cingulate, insula, ventromedial prefrontal, and …

Inhibitory neurotransmission plays a key role in anxiety disorders, as evidenced by the
anxiolytic effect of the benzodiazepine class of γ-aminobutyric acid (GABA) receptor …

Brain systems that promote the maintenance of homeostasis in face of stress have
significant adaptive value. A growing body of work across species demonstrates a critical …

Depression and anxiety disorders are the two most prevalent psychiatric diseases that affect
hundreds of millions of individuals worldwide. Understanding the etiology and related …

Alcohol addiction leads to increased choice of alcohol over healthy rewards. We established
an exclusive choice procedure in which~ 15% of outbred rats chose alcohol over a high …

A substantial number of people who have problems with alcohol also experience strong
anxiety and mood problems. This article provides an overview of the evolving perspectives …

Alcohol intake remains controlled in a majority of users but becomes “compulsive,” ie,
continues despite adverse consequences, in a minority who develop alcohol addiction …

Dysregulation of the corticotropin-releasing factor (CRF)–urocortin (UCN) system has been
implicated in stress-related psychopathologies such as depression and anxiety. It has been …

Stress is commonly regarded as an important trigger for relapse and a significant factor that
promotes increased motivation to drink in some individuals. However, the relationship …