Covering: 2000 to 2023 Cyanobacteria produce a variety of bioactive natural products that
can pose a threat to humans and animals as environmental toxins, but also have potential …

The use of protein sequence to inform enzymology in terms of structure, mechanism, and
function has burgeoned over the past two decades. Referred to as genomic enzymology, the …

Even in the genomic era, microbial natural product discovery workflows can be laborious
and limited in their ability to target molecules with specific structural features. Here we …

Incorporating enzymatic reactions into natural product synthesis can significantly improve
synthetic efficiency and selectivity. In contrast to the increasing applications of biocatalytic …

Microcystis spp. are renowned for producing the hepatotoxin microcystin in freshwater
cyanobacterial harmful algal blooms around the world, threatening drinking water supplies …

The Lewis acid-catalyzed Friedel–Crafts alkylation of an aromatic ring with an alkyl halide is
extensively used in organic synthesis. However, its biological counterpart was not reported …

Six new nostocyclophanes and four known compounds have been isolated from Nostoc
linckia (Nostocaceae) cyanobacterial strain UTEX B1932. The new compounds …

Macrocyclization reactions that are capable of stereoselectively co-creating one or more
stereogenic centers have become useful strategies for the effective syntheses of structurally …

Chemical tools and principles have become central to biological and medical
research/applications by leveraging a range of classical organic chemistry reactions. Friedel …

Halogenation significantly enhances the biological activity, stability, and solubility of organic
molecules, and thus is a crucial modification in the biotechnology and pharmaceutical …