Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

Protein design has come of age, but how will it mature? In the 1980s and the 1990s, the
primary motivation for de novo protein design was to test our understanding of the …

Natural metalloproteins perform many functions—ranging from sensing to electron transfer
and catalysis—in which the position and property of each ligand and metal are dictated by …

An important component of cellular biochemistry is the concentration of proteins and nucleic
acids in non-membranous compartments,. These biomolecular condensates are formed …

Motivation Coiled coils are protein structural domains that mediate a plethora of biological
interactions, and thus their reliable annotation is crucial for studies of protein structure and …

In order to fully understand any complex biochemical system from a mechanistic point of
view, it is necessary to have access to the three-dimensional structures of the molecular …

Proteins have evolved as a variable platform that provides access to molecules with diverse
shapes, sizes and functions. These features have inspired chemists for decades to seek …

Perceiving environmental and internal information and reacting in adaptive ways are
essential attributes of living organisms. Two-component systems are relevant protein …

The increased availability of user‐friendly and accessible computational tools for
biomolecular modeling would expand the reach and application of biomolecular …

Increasingly, it is possible to design peptide and protein assemblies de novo from first
principles or computationally. This approach provides new routes to functional synthetic …