Bone fractures are the most common traumatic injuries in humans. The repair of bone
fractures is a regenerative process that recapitulates many of the biological events of …

The discovery of osteoinductivity of calcium phosphate (Ca-P) ceramics has set an enduring
paradigm of conferring biological regenerative activity to materials with carefully designed …

The treatment of bone defects remains a significant challenge to be solved clinically.
Immunomodulatory properties of orthopedic biomaterials have significance in regulating …

Osteoporotic fractures are prevalent in society, and their incidence appears to be increasing
as the worldwide population ages. However, conventional bone repair materials hardly …

This essay analyzes the scientific evidence that forms the basis of bioactive materials,
covering the fundamental understanding of bioactivity phenomena and correlation with the …

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease known by the presence of
elevated blood glucose levels. Nowadays, it is perceived as a worldwide epidemic, with a …

Bone fractures represent a significant medical morbidity among aged population with
osteoporosis. Bone morphogenetic proteins (BMPs) are suggested to have therapeutic …

Tendon disease constitutes an unmet clinical need and remains a critical challenge in the
field of orthopaedic surgery. Innovative solutions are required to overcome the limitations of …

Abstract Background Cancer-associated fibroblasts (CAFs) are highly differentiated and
heterogeneous cancer-stromal cells that promote tumour growth, angiogenesis and matrix …

Bone morphogenetic proteins (BMPs) possess a unique ability to induce new bone
formation. Numerous preclinical studies have been conducted to develop novel, BMP-based …