Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

The brain has almost no energy reserve, but its activity coordinates organismal function, a
burden that requires precise coupling between neurotransmission and energy metabolism …

Although SARS-CoV-2 primarily targets the respiratory system, patients with and survivors of
COVID-19 can suffer neurological symptoms 1, 2, 3. However, an unbiased understanding …

Neurons are frequently classified into distinct types on the basis of structural, physiological,
or genetic attributes. To better constrain the definition of neuronal cell types, we …

The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles in
perception, cognition, emotion, and learning. We profiled∼ 1.3 million cells covering the …

We present a unique, extensive, and open synaptic physiology analysis platform and
dataset. Through its application, we reveal principles that relate cell type to synaptic …

Human brain development is underpinned by cellular and molecular reconfigurations
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …

The mechanisms underlying the pathophysiology and treatment of depression and stress-
related disorders remain unclear, but studies in depressed patients and rodent models are …

Top-down feedback in cortex is critical for guiding sensory processing, which has
prominently been formalized in the theory of hierarchical predictive coding (hPC). However …

Human brain organoids provide unique platforms for modeling development and diseases
by recapitulating the architecture of the embryonic brain. However, current organoid …