RNA can be modified by over 170 types of distinct chemical modifications, and the most
abundant internal modification of mRNA in eukaryotes is N6-methyladenosine (m 6 A). The …

Highlights•RNA-binding proteins (RBPs) are essential for tumorigenesis, immune evasion,
invasion, migration and metastasis, hence promising drug targets in cancer therapy.•Small …

Understanding of dedifferentiation, an indicator of poo prognosis for patients with thyroid
cancer, has been hampered by imprecise and incomplete characterization of its …

Cellular retinoic acid-binding protein 2 (CRABP2) participates in retinoid partitioning
between different nuclear receptors. Recently, we identified that CRABP2 is one of the …

The insulin-like growth factor-2 mRNA-binding proteins (IGF2BPs) pertain to a highly
conservative RNA-binding family that works as a post-transcriptional fine-tuner for target …

Aberrant lipid metabolism provides bioenergetic, biosynthetic, and redox supplies to cancer
cells. Previous studies have reported differential lipid profiling in thyroid malignancies. Sterol …

Simple Summary Anaplastic thyroid carcinoma (ATC) is a tumor with exceedingly high
mortality rates, and current treatment options are very limited once the disease has spread …

Cancer stem cells (CSCs) are considered as a small population of cells with stem-like
properties within the tumor bulk, and are largely responsible for tumor recurrence …

Abstract m 6 A methylation is the most frequent modification of mRNA in eukaryotes and
plays a crucial role in cancer progression by regulating biological functions. Insulin-like …

Purpose ATP-citrate lyase (ACLY) is a critical enzyme at the intersection of glucose and lipid
metabolism. ACLY is often upregulated or activated in cancer cells to accelerate lipid …