Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

JS Loh, WQ Mak, LKS Tan, CX Ng, HH Chan… - … and Targeted Therapy, 2024 - nature.com
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Neuroimmune Interactions in the Intestine

A Wallrapp, IM Chiu - Annual Review of Immunology, 2024 - annualreviews.org
Recent advances have contributed to a mechanistic understanding of neuroimmune
interactions in the intestine and revealed an essential role of this cross talk for gut …

Gut butyrate-producers confer post-infarction cardiac protection

HC Chen, YW Liu, KC Chang, YW Wu, YM Chen… - Nature …, 2023 - nature.com
The gut microbiome and its metabolites are increasingly implicated in several
cardiovascular diseases, but their role in human myocardial infarction (MI) injury responses …

A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut

Y Zhu, KA Meerschaert, S Galvan-Pena, NR Bin… - Science, 2024 - science.org
Neuroimmune cross-talk participates in intestinal tissue homeostasis and host defense.
However, the matrix of interactions between arrays of molecularly defined neuron subsets …

Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells

P Wang, N Kljavin, TTT Nguyen, EE Storm, B Marsh… - Cell Stem Cell, 2023 - cell.com
The intestinal epithelium has high intrinsic turnover rate, and the precise renewal of the
epithelium is dependent on the microenvironment. The intestine is innervated by a dense …

The role of cellular and molecular neuroimmune crosstalk in gut immunity

D Yang, N Almanzar, IM Chiu - Cellular & Molecular Immunology, 2023 - nature.com
The gastrointestinal tract is densely innervated by the peripheral nervous system and
populated by the immune system. These two systems critically coordinate the sensations of …

The importance of the gut microbiome and its signals for a healthy nervous system and the multifaceted mechanisms of neuropsychiatric disorders

L Riehl, J Fürst, M Kress, N Rykalo - Frontiers in Neuroscience, 2024 - frontiersin.org
Increasing evidence links the gut microbiome and the nervous system in health and disease.
This narrative review discusses current views on the interaction between the gut microbiota …

Neolignans in Magnolia officinalis as natural anti-Alzheimer's disease agents: A systematic review

N Li, Y Liang, L Zhang, C Xu, L Wang - Ageing Research Reviews, 2024 - Elsevier
Background Magnolia officinalis, a traditional herbal medicine widely used in clinical
practice, exerts antibacterial, anti-tumor, anti-inflammatory, antioxidant, and anti-aging …

The neuroimmune CGRP–RAMP1 axis tunes cutaneous adaptive immunity to the microbiota

W Kulalert, AC Wells, VM Link, AI Lim… - Proceedings of the …, 2024 - National Acad Sciences
The somatosensory nervous system surveils external stimuli at barrier tissues, regulating
innate immune cells under infection and inflammation. The roles of sensory neurons in …

Current aspects of small extracellular vesicles in pain process and relief

L Zhang, J Liu, C Zhou - Biomaterials Research, 2023 - spj.science.org
Small extracellular vesicles (sEVs) have been identified as a noteworthy paracrine
mechanism of intercellular communication in diagnosing and managing neurological …