Zic genes are strongly expressed in the cerebellum. This feature leads to their initial
identification and their name “zic,” as the abbreviation of “zinc finger protein of the …

The enormous expansion the vertebrate nervous system goes through from its first anlage to
its adult shape and organization goes along with extensive rearrangements of its constituent …

Preterm birth disrupts cerebellar development, which may be mediated by systemic
oxidative stress that damages neuronal developmental stages. Impaired cerebellar …

Impaired cerebellar development of premature infants and the associated impairment of
cerebellar functions in cognitive development could be crucial factors for …

Misoriented division of neuroprogenitors, by loss-of-function studies of centrosome or
spindle components, has been linked to the developmental brain defects microcephaly and …

The developing cerebellum of amniotes is characterised by a unique, transient, secondary
proliferation zone: the external germinal layer (EGL). The EGL is comprised solely of granule …

Spinster homolog 2 (SPNS2) is the membrane transporter of sphingosine‐1‐phosphate
(S1P), and it participates in several physiologic processes by activating different S1P …

During neural development, stem and precursor cells can divide either symmetrically or
asymmetrically. The transition between symmetric and asymmetric cell divisions is a major …

Background Medulloblastoma is a pediatric malignant brain tumor associated with an
aberrantly activated Shh pathway. The Shh pathway acts via downstream effector …

The cerebellar granule cell (GC) system provides a good model for studying neuronal
development. In the external granule layer (EGL), granule cell precursors (GCPs) rapidly …