Primary liver cancer is the second leading cause of cancer-related death worldwide and
therefore a major public health challenge. We review hypotheses of the cell of origin of liver …

The term next-generation sequencing is almost a decade old, but it remains the colloquial
way to describe highly parallel or high-output sequencing methods that produce data at or …

Background & Aims Intraductal oncocytic papillary neoplasms (IOPNs) of the pancreas and
bile duct contain epithelial cells with numerous, large mitochondria and are cystic precursors …

Fibrolamellar carcinoma (FLC) is a lethal primary liver cancer, affecting young patients in
absence of chronic liver disease. Molecular understanding of FLC tumorigenesis is limited …

Recently discovered DNAJB1-PRKACA oncogenic fusions have been considered
diagnostic for fibrolamellar hepatocellular carcinoma. In this study, we describe six …

Liver cancer is the second most common cause of cancer-related death. The major forms of
primary liver cancer are hepatocellular carcinoma (HCC) and intrahepatic …

A segmental deletion resulting in DNAJB1–PRKACA gene fusion is now recognized as the
signature genetic event of fibrolamellar hepatocellular carcinoma (FL-HCC), a rare but lethal …

Genetic alterations that activate protein kinase A (PKA) are found in many tumor types. Yet,
their downstream oncogenic signaling mechanisms are poorly understood. We used global …

More than a decade ago, the term “next-generation” sequencing was coined to describe
what was, at the time, revolutionary new methods to sequence RNA and DNA at a faster …

Fibrolamellar carcinoma (FLC), a rare, lethal hepatic cancer, occurs primarily in adolescents
and young adults. Unlike hepatocellular carcinoma, FLC has no known association with …