From mollusks to medicine: a venomics approach for the discovery and characterization of therapeutics from Terebridae peptide toxins
Animal venoms comprise a diversity of peptide toxins that manipulate molecular targets such
as ion channels and receptors, making venom peptides attractive candidates for the …
as ion channels and receptors, making venom peptides attractive candidates for the …
Utilisation of compounds from venoms in drug discovery
Difficult drug targets are becoming the normal course of business in drug discovery,
sometimes due to large interacting surfaces or only small differences in selectivity regions …
sometimes due to large interacting surfaces or only small differences in selectivity regions …
Polypharmacological cell-penetrating peptides from venomous marine animals based on immunomodulating, antimicrobial, and anticancer properties
S Hemmati, H Rasekhi Kazerooni - Marine Drugs, 2022 - mdpi.com
Complex pathological diseases, such as cancer, infection, and Alzheimer's, need to be
targeted by multipronged curative. Various omics technologies, with a high rate of data …
targeted by multipronged curative. Various omics technologies, with a high rate of data …
Melittin antimicrobial peptide thin layer on bone implant chitosan-antibiotic coatings and their bactericidal properties
V Zarghami, M Ghorbani, KP Bagheri… - Materials Chemistry and …, 2021 - Elsevier
Antibiotics resistant bacteria and biofilm formation on bone implants are the main challenges
of present treatment methods in hip or joint replacement surgeries. Recently, antimicrobial …
of present treatment methods in hip or joint replacement surgeries. Recently, antimicrobial …
Unveiling the Venom Composition of the Colombian Coral Snakes Micrurus helleri, M. medemi, and M. sangilensis
A Rodríguez-Vargas, AM Franco-Vásquez… - Toxins, 2023 - mdpi.com
Little is known of the biochemical composition and functional features of the venoms of
poorly known Colombian coral snakes. Here, we provide a preliminary characterization of …
poorly known Colombian coral snakes. Here, we provide a preliminary characterization of …
Action mechanism of melittin-derived antimicrobial peptides, MDP1 and MDP2, de novo designed against multidrug resistant bacteria
The emergence and dissemination of multidrug resistant (MDR) bacteria are major
challenges for antimicrobial chemotherapy of bacterial infections. In this critical condition …
challenges for antimicrobial chemotherapy of bacterial infections. In this critical condition …
Single dose eradication of extensively drug resistant Acinetobacter spp. in a mouse model of burn infection by melittin antimicrobial peptide
F Pashaei, P Bevalian, R Akbari, KP Bagheri - Microbial pathogenesis, 2019 - Elsevier
Bacterial infections caused by antibiotic resistant bacteria are the leading cause of morbidity
and mortality after burn injuries. This issue has driven the need for promising antimicrobial …
and mortality after burn injuries. This issue has driven the need for promising antimicrobial …
Novel chloroquine loaded curcumin based anionic linear globular dendrimer G2: A metabolomics study on Plasmodium falciparum in vitro using 1H NMR …
T Elmi, MS Ardestani, F Hajialiani, M Motevalian… - Parasitology, 2020 - cambridge.org
Due to side-effects and inefficiency of the drugs used in malaria treatment, finding alternative
medicine with less side-effects has attracted much attention. In this regard, in the present …
medicine with less side-effects has attracted much attention. In this regard, in the present …
Fast killing kinetics, significant therapeutic index, and high stability of melittin-derived antimicrobial peptide
R Akbari, M Hakemi Vala, JM Sabatier… - Amino Acids, 2022 - Springer
The emergence of multidrug-resistant (MDR) bacteria is a major challenge for antimicrobial
chemotherapy. Concerning this issue, antimicrobial peptides (AMPs) have been presented …
chemotherapy. Concerning this issue, antimicrobial peptides (AMPs) have been presented …
Discovery of a New Analgesic Peptide, Leptucin, from the Iranian Scorpion, Hemiscorpius lepturus
S Bagheri-Ziari, D Shahbazzadeh, S Sardari… - Molecules, 2021 - mdpi.com
Hemiscorpius lepturus scorpion stings do not induce considerable pain based on
epidemiological surveys conducted in the southwest part of Iran. Accordingly, this study was …
epidemiological surveys conducted in the southwest part of Iran. Accordingly, this study was …