From mollusks to medicine: a venomics approach for the discovery and characterization of therapeutics from Terebridae peptide toxins

A Verdes, P Anand, J Gorson, S Jannetti, P Kelly… - Toxins, 2016 - mdpi.com
Animal venoms comprise a diversity of peptide toxins that manipulate molecular targets such
as ion channels and receptors, making venom peptides attractive candidates for the …

Utilisation of compounds from venoms in drug discovery

CM Trim, LJ Byrne, SA Trim - Progress in Medicinal Chemistry, 2021 - Elsevier
Difficult drug targets are becoming the normal course of business in drug discovery,
sometimes due to large interacting surfaces or only small differences in selectivity regions …

Polypharmacological cell-penetrating peptides from venomous marine animals based on immunomodulating, antimicrobial, and anticancer properties

S Hemmati, H Rasekhi Kazerooni - Marine Drugs, 2022 - mdpi.com
Complex pathological diseases, such as cancer, infection, and Alzheimer's, need to be
targeted by multipronged curative. Various omics technologies, with a high rate of data …

Melittin antimicrobial peptide thin layer on bone implant chitosan-antibiotic coatings and their bactericidal properties

V Zarghami, M Ghorbani, KP Bagheri… - Materials Chemistry and …, 2021 - Elsevier
Antibiotics resistant bacteria and biofilm formation on bone implants are the main challenges
of present treatment methods in hip or joint replacement surgeries. Recently, antimicrobial …

Unveiling the Venom Composition of the Colombian Coral Snakes Micrurus helleri, M. medemi, and M. sangilensis

A Rodríguez-Vargas, AM Franco-Vásquez… - Toxins, 2023 - mdpi.com
Little is known of the biochemical composition and functional features of the venoms of
poorly known Colombian coral snakes. Here, we provide a preliminary characterization of …

Action mechanism of melittin-derived antimicrobial peptides, MDP1 and MDP2, de novo designed against multidrug resistant bacteria

R Akbari, M Hakemi Vala, A Hashemi, H Aghazadeh… - Amino acids, 2018 - Springer
The emergence and dissemination of multidrug resistant (MDR) bacteria are major
challenges for antimicrobial chemotherapy of bacterial infections. In this critical condition …

Single dose eradication of extensively drug resistant Acinetobacter spp. in a mouse model of burn infection by melittin antimicrobial peptide

F Pashaei, P Bevalian, R Akbari, KP Bagheri - Microbial pathogenesis, 2019 - Elsevier
Bacterial infections caused by antibiotic resistant bacteria are the leading cause of morbidity
and mortality after burn injuries. This issue has driven the need for promising antimicrobial …

Novel chloroquine loaded curcumin based anionic linear globular dendrimer G2: A metabolomics study on Plasmodium falciparum in vitro using 1H NMR …

T Elmi, MS Ardestani, F Hajialiani, M Motevalian… - Parasitology, 2020 - cambridge.org
Due to side-effects and inefficiency of the drugs used in malaria treatment, finding alternative
medicine with less side-effects has attracted much attention. In this regard, in the present …

Fast killing kinetics, significant therapeutic index, and high stability of melittin-derived antimicrobial peptide

R Akbari, M Hakemi Vala, JM Sabatier… - Amino Acids, 2022 - Springer
The emergence of multidrug-resistant (MDR) bacteria is a major challenge for antimicrobial
chemotherapy. Concerning this issue, antimicrobial peptides (AMPs) have been presented …

Discovery of a New Analgesic Peptide, Leptucin, from the Iranian Scorpion, Hemiscorpius lepturus

S Bagheri-Ziari, D Shahbazzadeh, S Sardari… - Molecules, 2021 - mdpi.com
Hemiscorpius lepturus scorpion stings do not induce considerable pain based on
epidemiological surveys conducted in the southwest part of Iran. Accordingly, this study was …