Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …

Microbes are known to colonize surfaces and form biofilms. These biofilms are communities
of microbes encased in a self-produced matrix that often contains polysaccharides, DNA and …

Nearly 80% of human chronic infections are caused due to bacterial biofilm formation. This
is the most leading cause for failure of medical implants resulting in high morbidity and …

The great clinical significance of biofilm-associated infections and their inherent
recalcitrance to antibiotic treatment urgently demand the development of novel antibiofilm …

Mycobacterium tuberculosis (Mtb) is one of the most important infectious agents worldwide
and causes more than 1.5 million deaths annually. To make matters worse, the drug …

The accelerated appearance of drug-resistant bacteria poses an ever-growing threat to
modern medicine's capacity to fight infectious diseases. Gram-positive species such as …

Highlights•To date no antibiotics have been specifically developed for biofilm infections.•Anti-
biofilm peptides directly address chronic multi-resistant bacterial infections.•They …

New strategies are urgently needed to target MRSA, a major global health problem and the
leading cause of mortality from antibiotic-resistant infections in many countries. Here, we …

The rise of antibiotic-resistant strains of bacterial pathogens has necessitated the
development of new therapeutics. Antimicrobial peptides (AMPs) are a class of compounds …

Glycopeptides, a class of cell wall biosynthesis inhibitors, have been the antibiotics of choice
against drug-resistant Gram-positive bacterial infections. Their unique mechanism of action …