Weight management in patients with type 1 diabetes and obesity

A Mottalib, M Kasetty, JY Mar, T Elseaidy… - Current diabetes …, 2017 - Springer
Purpose of review Patients with type 1 diabetes (T1D) are typically viewed as lean
individuals. However, recent reports showed that their obesity rate surpassed that of the …

Obesity in patients with type 1 diabetes: links, risks and management challenges

N Vilarrasa, P San Jose, MÁ Rubio… - … Syndrome and Obesity, 2021 - Taylor & Francis
Obesity affects large numbers of patients with type 1 diabetes (T1D) across their lifetime,
with rates ranging between 2.8% and 37.1%. Patients with T1D and obesity are …

Insulin‐associated weight gain in obese type 2 diabetes mellitus patients: What can be done?

A Brown, N Guess, A Dornhorst… - Diabetes, Obesity and …, 2017 - Wiley Online Library
Insulin therapy (IT) is initiated for patients with type 2 diabetes mellitus when glycaemic
targets are not met with diet and other hypoglycaemic agents. The initiation of IT improves …

Impact of weight gain on outcomes in type 2 diabetes

SA Ross, G Dzida, J Vora, K Khunti… - … medical research and …, 2011 - Taylor & Francis
Background: The majority of patients with type 2 diabetes mellitus (T2DM) are overweight or
obese. Obesity is a significant risk factor for increased morbidity and mortality in people with …

An exhaustive perspective on structural insights of SGLT2 inhibitors: A novel class of antidiabetic agent

S Bhattacharya, A Rathore, D Parwani, C Mallick… - European Journal of …, 2020 - Elsevier
Diabetes mellitus is the global health issue and become an alarming threat in the modern
era where human lifestyle gets compromised with modernization. According to the latest …

Once‐daily initiation of basal insulin as add‐on to metformin: a 26‐week, randomized, treat‐to‐target trial comparing insulin detemir with insulin glargine in patients …

L Meneghini, J Kesavadev, M Demissie… - Diabetes, obesity …, 2013 - Wiley Online Library
Aims This study assessed the efficacy and safety of once‐daily insulin initiation using insulin
detemir (detemir) or insulin glargine (glargine) added to existing metformin in type 2 …

The Why WAIT program: improving clinical outcomes through weight management in type 2 diabetes

O Hamdy, C Carver - Current diabetes reports, 2008 - Springer
Targeting body weight, as an alternative model to targeting hemoglobin A 1c, is emerging as
a viable and potentially cost-effective approach to diabetes management in clinical practice …

Insulin detemir: a review of its use in the management of diabetes mellitus

GM Keating - Drugs, 2012 - Springer
Insulin detemir (Levemir®) is a long-acting insulin analogue indicated for use as basal
insulin therapy in patients with type 1 or 2 diabetes mellitus. The protracted action of insulin …

PEGylated insulin Lispro,(LY2605541)—a new basal insulin analogue

TM Caparrotta, M Evans - Diabetes, Obesity and Metabolism, 2014 - Wiley Online Library
There is a clinical rationale for a basal insulin with a predictable action and low inter‐and
intra‐individual variability coupled with an improved side effect and metabolic profile. Since …

Efficacy and safety of insulin detemir once daily in combination with sitagliptin and metformin: the TRANSITION randomized controlled trial

P Hollander, K Raslova, TV Skjøth… - Diabetes, Obesity …, 2011 - Wiley Online Library
Aim: The aim of this trial was to evaluate the efficacy and safety of the combination of once‐
daily insulin detemir (IDet) and sitagliptin (SITA) versus SITA±sulphonylurea (SU), both in …