Saccular intracranial aneurysm: pathology and mechanisms

J Frösen, R Tulamo, A Paetau, E Laaksamo… - Acta …, 2012 - Springer
Saccular intracranial aneurysms (sIA) are pouch-like pathological dilatations of intracranial
arteries that develop when the cerebral artery wall becomes too weak to resist …

Patient-specific modeling of cardiovascular mechanics

CA Taylor, CA Figueroa - Annual review of biomedical …, 2009 - annualreviews.org
Advances in numerical methods and three-dimensional imaging techniques have enabled
the quantification of cardiovascular mechanics in subject-specific anatomic and physiologic …

The critical role of hemodynamics in the development of cerebral vascular disease: a review

AM Nixon, M Gunel, BE Sumpio - Journal of neurosurgery, 2010 - thejns.org
Atherosclerosis and intracranial saccular aneurysms predictably localize in areas with
complex arterial geometries such as bifurcations and curvatures. These sites are …

Wall shear stress on ruptured and unruptured intracranial aneurysms at the internal carotid artery

LD Jou, DH Lee, H Morsi… - American Journal of …, 2008 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Hemodynamics is often recognized as one of the major
factors in aneurysm rupture. Flow impingement, greater pressure, and abnormal wall shear …

Intracranial and abdominal aortic aneurysms: similarities, differences, and need for a new class of computational models

JD Humphrey, CA Taylor - Annu. Rev. Biomed. Eng., 2008 - annualreviews.org
Intracranial saccular and abdominal aortic aneurysms (ISAs and AAAs, respectively) result
from different underlying disease processes and exhibit different rupture potentials, yet they …

CFD: computational fluid dynamics or confounding factor dissemination? The role of hemodynamics in intracranial aneurysm rupture risk assessment

J Xiang, VM Tutino, KV Snyder… - American Journal of …, 2014 - Am Soc Neuroradiology
Image-based computational fluid dynamics holds a prominent position in the evaluation of
intracranial aneurysms, especially as a promising tool to stratify rupture risk. Current …

Intracranial aneurysms: links among inflammation, hemodynamics and vascular remodeling

T Hashimoto, H Meng, WL Young - Neurological research, 2006 - Taylor & Francis
Abnormal vascular remodeling mediated by inflammatory cells has been identified as a key
pathologic component of various vascular diseases, including abdominal aortic aneurysms …

Role of fluid dynamics and inflammation in intracranial aneurysm formation

AS Turjman, F Turjman, ER Edelman - Circulation, 2014 - Am Heart Assoc
374 Circulation January 21, 2014 to vascular aneurysms, we surmise that aneurysm-
protective flows and wall states maintain vascular homeostasis throughout the cerebral tree …

Using computational fluid dynamics analysis to characterize local hemodynamic features of middle cerebral artery aneurysm rupture points

K Fukazawa, F Ishida, Y Umeda, Y Miura… - World neurosurgery, 2015 - Elsevier
Objective Although rupture of cerebral aneurysms typically occurs at the fragile wall at the
apex or pole, some aneurysms rupture through the body or the neck. The purpose of this …

Physical factors effecting cerebral aneurysm pathophysiology

C Sadasivan, DJ Fiorella, HH Woo… - Annals of biomedical …, 2013 - Springer
Many factors that are either blood-, wall-, or hemodynamics-borne have been associated
with the initiation, growth, and rupture of intracranial aneurysms. The distribution of cerebral …