Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …

Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-
specific characterization of DNAm is needed to understand its role in gene regulation and its …

Technological advances in genomics and imaging have led to an explosion of molecular
and cellular profiling data from large numbers of samples. This rapid increase in biological …

We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …

The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …

Background It is not yet known whether DNA methylation levels can be used to accurately
predict age across a broad spectrum of human tissues and cell types, nor whether the …

Background DNA methylation is an important feature of plant epigenomes, involved in the
formation of heterochromatin and affecting gene expression. Extensive variation of DNA …

Background The influence of genetic variation on complex diseases is potentially mediated
through a range of highly dynamic epigenetic processes exhibiting temporal variation during …

The ability to measure human aging from molecular profiles has practical implications in
many fields, including disease prevention and treatment, forensics, and extension of life …