Network pharmacology: curing causal mechanisms instead of treating symptoms
For complex diseases, most drugs are highly ineffective, and the success rate of drug
discovery is in constant decline. While low quality, reproducibility issues, and translational …
discovery is in constant decline. While low quality, reproducibility issues, and translational …
[HTML][HTML] Redox-related biomarkers in human cardiovascular disease-classical footprints and beyond
Global epidemiological studies show that chronic non-communicable diseases such as
atherosclerosis and metabolic disorders represent the leading cause of premature mortality …
atherosclerosis and metabolic disorders represent the leading cause of premature mortality …
Computational approaches leveraging integrated connections of multi-omic data toward clinical applications
In line with the advances in high-throughput technologies, multiple omic datasets have
accumulated to study biological systems and diseases coherently. No single omics data type …
accumulated to study biological systems and diseases coherently. No single omics data type …
Detection of extracellular superoxide in isolated human immune cells and in an animal model of arterial hypertension using hydropropidine probe and HPLC analysis
S Kalinovic, P Stamm, M Oelze, S Steven… - Free Radical Biology …, 2021 - Elsevier
Superoxide formation is a hallmark of cardiovascular disease with the involvement of
different tissues and cell types. Identification of the cellular sources and subcellular …
different tissues and cell types. Identification of the cellular sources and subcellular …
Classifying diseases by using biological features to identify potential nosological models
Established nosological models have provided physicians an adequate enough
classification of diseases so far. Such systems are important to correctly identify diseases …
classification of diseases so far. Such systems are important to correctly identify diseases …
Implications of NADPH oxidase 5 in vascular diseases
J Marqués, A Cortés, Á Pejenaute, G Zalba - The International Journal of …, 2020 - Elsevier
Oxidative stress is one of the main mechanisms involved in the pathophysiology of vascular
diseases. Among others, oxidative stress promotes endothelial dysfunction, and accelerated …
diseases. Among others, oxidative stress promotes endothelial dysfunction, and accelerated …
In search of newer targets for inflammatory bowel disease: a systems and a network medicine approach
T Kitani, SC Maddipatla, R Madupuri… - Network and Systems …, 2021 - liebertpub.com
Introduction: Crohn's disease and ulcerative colitis, both under the umbrella of inflammatory
bowel diseases (IBD), involve many distinct molecular processes. The difference in their …
bowel diseases (IBD), involve many distinct molecular processes. The difference in their …
In Search of Newer Targets for IBD: A Systems and a Network Medicine Approach
T Kitani, SC Maddipatla, R Madupuri… - arXiv preprint arXiv …, 2020 - arxiv.org
Introduction: Crohn's disease and ulcerative colitis, both under the umbrella of inflammatory
bowel diseases (IBD), involve many distinct molecular processes. The difference in their …
bowel diseases (IBD), involve many distinct molecular processes. The difference in their …