Islet transplantation can restore lost glycemic control in type 1 diabetes subjects but is
restricted in its clinical application by a limiting supply of islets and the need for heavy …

Nuclear factor κB (NF-κB) activation is a deleterious molecular mechanism that drives acute
kidney injury (AKI) and manifests in transplanted kidneys as delayed graft function. The …

Abstract Background Neonatal porcine islets (NPIs) can restore glucose control in mice,
pigs, and non‐human primates, representing a potential abundant alternative islet supply for …

Aims/hypothesis NF-κB activation unites metabolic and inflammatory responses in many
diseases yet less is known about the role that NF-κB plays in normal metabolism. In this …

In 1976, Lafferty et al. 1 demonstrated that “passenger leukocytes” within the transplanted
allograft are key mediators of acute rejection. Although this finding provoked intense interest …

Younger pigs only require the mothers to be held for long term, whereas the isolation of
adult pig islets requires significant infrastructure and expense as the pigs for islet isolation …