Cellular and molecular mechanisms of Hedgehog signalling
The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning,
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …
A highlight on Sonic hedgehog pathway
GB Carballo, JR Honorato, GPF de Lopes… - Cell Communication and …, 2018 - Springer
Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic
development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is …
development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is …
Non-canonical hedgehog signaling pathway in cancer: activation of GLI transcription factors beyond smoothened
S Pietrobono, S Gagliardi, B Stecca - Frontiers in genetics, 2019 - frontiersin.org
The Hedgehog-GLI (HH-GLI) pathway is a highly conserved signaling that plays a critical
role in controlling cell specification, cell–cell interaction and tissue patterning during …
role in controlling cell specification, cell–cell interaction and tissue patterning during …
Randomized phase Ib/II study of gemcitabine plus placebo or vismodegib, a hedgehog pathway inhibitor, in patients with metastatic pancreatic cancer
DVT Catenacci, MR Junttila, T Karrison… - Journal of Clinical …, 2015 - ascopubs.org
Purpose Sonic hedgehog (SHH), an activating ligand of smoothened (SMO), is
overexpressed in> 70% of pancreatic cancers (PCs). We investigated the impact of …
overexpressed in> 70% of pancreatic cancers (PCs). We investigated the impact of …
Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition
Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven
medulloblastoma (SHH-MB). Clinical response is highly variable. To understand the …
medulloblastoma (SHH-MB). Clinical response is highly variable. To understand the …
Vismodegib exerts targeted efficacy against recurrent sonic hedgehog–subgroup medulloblastoma: results from phase II pediatric brain tumor consortium studies …
Purpose Two phase II studies assessed the efficacy of vismodegib, a sonic hedgehog (SHH)
pathway inhibitor that binds smoothened (SMO), in pediatric and adult recurrent …
pathway inhibitor that binds smoothened (SMO), in pediatric and adult recurrent …
Cellular cholesterol directly activates smoothened in hedgehog signaling
P Huang, D Nedelcu, M Watanabe, C Jao, Y Kim, J Liu… - Cell, 2016 - cell.com
In vertebrates, sterols are necessary for Hedgehog signaling, a pathway critical in
embryogenesis and cancer. Sterols activate the membrane protein Smoothened by binding …
embryogenesis and cancer. Sterols activate the membrane protein Smoothened by binding …
Smoothened stimulation by membrane sterols drives Hedgehog pathway activity
I Deshpande, J Liang, D Hedeen, KJ Roberts, Y Zhang… - Nature, 2019 - nature.com
Hedgehog signalling is fundamental to embryonic development and postnatal tissue
regeneration. Aberrant postnatal Hedgehog signalling leads to several malignancies …
regeneration. Aberrant postnatal Hedgehog signalling leads to several malignancies …
Smoothened variants explain the majority of drug resistance in basal cell carcinoma
Advanced basal cell carcinomas (BCCs) frequently acquire resistance to Smoothened
(SMO) inhibitors through unknown mechanisms. Here we identify SMO mutations in 50%(22 …
(SMO) inhibitors through unknown mechanisms. Here we identify SMO mutations in 50%(22 …
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
D Amakye, Z Jagani, M Dorsch - Nature medicine, 2013 - nature.com
Major progress has been made in recent years in the development of Hedgehog (Hh)
pathway inhibitors for the treatment of patients with cancer. Promising clinical trial results …
pathway inhibitors for the treatment of patients with cancer. Promising clinical trial results …