Bacterial pathogens as causative agents of infection constitute an alarming concern in the
public health sector. In particular, bacteria with resistance to multiple antimicrobial agents …

Following the discovery of penicillin, which was inactive against Mycobacterium
tuberculosis, Waksman discovered the first antituberculosis agent, streptomycin, by …

Alteration in the target sites of antibiotics is a common mechanism of resistance. Examples
of clinical strains showing resistance can be found for every class of antibiotic, regardless of …

Termination of protein synthesis is not 100% efficient. A number of natural mechanisms that
suppress translation termination exist. One of them is STOP codon readthrough, the process …

ABSTRACT A self-transferable plasmid of ca. 80 kb, pIP1204, conferred multiple-antibiotic
resistance to Klebsiella pneumoniae BM4536, which was isolated from a urinary tract …

▪ Abstract The ribosome discriminates between correct and incorrect aminoacyl-tRNAs (aa-
tRNAs), or their complexes with elongation factor Tu (EF-Tu) and GTP, according to the …

The aminoglycosides, a group of structurally related antibiotics, bind to rRNA in the small
subunit of the prokaryotic ribosome. Most aminoglycosides are inactive or weakly active …

The ribosome decoding center is rich in modified rRNA nucleotides and little is known about
their effects. Here, we examine the consequences of systematically deleting eight …

Translational fidelity is established by ribosomal recognition of the codon-anticodon
interaction within the aminoacyl–transfer RNA (tRNA) site (A site) of the ribosome …

We have isolated a multiple-aminoglycoside-resistant Escherichia coli strain, strain ARS3,
and have been the first to identify a novel plasmid-mediated 16S rRNA methyltransferase …