Post-transplant diabetes mellitus (PTDM) is a frequent consequence of solid organ
transplantation. PTDM has been associated with greater mortality and increased infections …

The treatment of diabetes mellitus represents one of the greatest medical challenges of our
era. Diabetes results from a deficiency or functional impairment of insulin-producing β cells …

Inadequate pancreatic β cell function underlies type 1 and type 2 diabetes mellitus.
Strategies to expand functional cells have focused on discovering and controlling …

Although loss of functional β-cell mass is a hallmark of diabetes, no treatment approaches
that halt this process are currently available. We recently identified thioredoxin-interacting …

Pancreatic beta (β) cell dysfunction results in compromised insulin release and, thus, failed
regulation of blood glucose levels. This forms the backbone of the development of diabetes …

Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple
sclerosis, and adrenal dysfunction, but its function is unknown. Here we report that Clec16a …

The second messenger cyclic AMP (cAMP) can either stimulate or inhibit programmed cell
death (apoptosis). Here, we review examples of cell types that show pro‐apoptotic or anti …

The endoplasmic reticulum (ER) mediates the first steps of protein assembly within the
secretory pathway and is the site where protein folding and quality control are initiated. The …

Calcineurin inhibitors (CNIs), including tacrolimus and cyclosporine, are immune‐
modulating agents used in autoimmune disorders, glomerulonephritides, and after …

Abstract The dynamin-like GTPases Mitofusin 1 and 2 (Mfn1 and Mfn2) are essential for
mitochondrial function, which has been principally attributed to their regulation of …