Organisms as diverse as microbes, roundworms, insects, and mammals detect and respond
to applied force. In animals, this ability depends on ionotropic force receptors, known as …

In the inner ear, the auditory and vestibular systems detect and translate sensory information
regarding sound and balance. The sensory cells that transform mechanical input into an …

The initial step in the sensory transduction pathway underpinning hearing and balance in
mammals involves the conversion of force into the gating of a mechanosensory transduction …

Hearing and balance involve the transduction of mechanical stimuli into electrical signals by
deflection of bundles of stereocilia linked together by protocadherin 15 (PCDH15) and …

Cadherins form a large family of proteins often involved in calcium-dependent cellular
adhesion. Although classical members of the family can provide a physical bond between …

Physical contact with the external world occurs through specialized neural structures called
mechanoreceptors. Cutaneous mechanoreceptors provide information to the central …

Wearable devices (wearables) have recently gained significant traction and are predicted to
dominate many areas of research over the next 5 years. Many wearables contain a host of …

In vertebrate hearing organs, mechanical vibrations are converted to ionic currents through
mechanoelectrical-transduction (MET) channels. Concerted stereocilia motion produces an …

The ability to sense mechanical stimuli and elaborate a response to them is a fundamental
process in all organisms, driving crucial mechanisms ranging from cell volume regulation up …

Cochlear hair cells normally detect positive deflections of their hair bundles, rotating toward
their tallest edge, which opens mechanotransducer (MT) channels by increased tension in …