Pluripotent stem cells show a remarkable ability to self-organize and differentiate in vitro in
three-dimensional aggregates, known as organoids or organ spheroids, and to recapitulate …

The vertebrate spinal cord comprises multiple functionally distinct neuronal cell types
arranged in characteristic positions. During development, these different types of neurons …

Neuromuscular networks assemble during early human embryonic development and are
essential for the control of body movement. Previous neuromuscular junction modeling …

Human spinal-cord-like tissues induced from human pluripotent stem cells are typically
insufficiently mature and do not mimic the morphological features of neurulation. Here, we …

There is growing interest in the use of neural precursor cells to treat spinal cord injury (SCI).
Despite extensive pre-clinical research, it remains unclear as to which donor neuron …

Motor and sensory functions of the spinal cord are mediated by populations of cardinal
neurons arising from separate progenitor lineages. However, each cardinal class is …

Axis formation and related spatial patterning are initiated by symmetry breaking during
development. A geometrically confined culture of human pluripotent stem cells (hPSCs) …

Motor neurons project axons from the hindbrain and spinal cord to muscle, where they
induce myofibre contractions through neurotransmitter release at neuromuscular junctions …

Disruption of homeostatic microRNA (miRNA) expression levels is known to cause human
neuropathology. However, the gene regulatory and phenotypic effects of altering a miRNA's …

V2a interneurons are located in the hindbrain and spinal cord, where they provide rhythmic
input to major motor control centers. Many of the phenotypic properties and functions of …