Clinical significance of head and neck squamous cell cancer biomarkers

H Polanska, M Raudenska, J Gumulec… - Oral oncology, 2014 - Elsevier
Head and neck tumors belong among the six leading causes of cancer death worldwide.
The predominant type of head and neck tumors consists of squamous cell carcinomas …

Lymph node ratio as prognostic variable in oral squamous cell carcinomas: systematic review and meta-analysis

TH Huang, KY Li, WS Choi - Oral oncology, 2019 - Elsevier
Lymph node ratio (LNR) has been shown to be an independent prognostic factor for oral
squamous cell carcinoma (OSCC) in various centre-based studies recently. A range of cut …

Primary tumor staging for oral cancer and a proposed modification incorporating depth of invasion: an international multicenter retrospective study

A Ebrahimi, Z Gil, M Amit, TC Yen… - … –Head & Neck …, 2014 - jamanetwork.com
Importance The current American Joint Committee on Cancer (AJCC) staging system for oral
cancer demonstrates wide prognostic variability within each primary tumor stage and …

Predictive value of tumor thickness for cervical lymph‐node involvement in squamous cell carcinoma of the oral cavity: a meta‐analysis of reported studies

SH Huang, D Hwang, G Lockwood… - … Journal of the …, 2009 - Wiley Online Library
BACKGROUND: Tumor thickness (TT) appears to be a strong predictor for cervical lymph‐
node involvement in squamous cell carcinoma of the oral cavity (OSCC), but a precise …

Head and Neck Squamous Cell Carcinoma: Value of Diffusion-weighted MR Imaging for Nodal Staging1

V Vandecaveye, F De Keyzer, V Vander Poorten… - Radiology, 2009 - pubs.rsna.org
Purpose: To evaluate diffusion-weighted (DW) magnetic resonance (MR) imaging, as
compared with turbo spin-echo MR imaging, for the detection of nodal metastases in head …

Tumor thickness versus depth of invasion–Analysis of the 8th edition American Joint Committee on Cancer Staging for oral cancer

R Dirven, A Ebrahimi, N Moeckelmann, CE Palme… - Oral oncology, 2017 - Elsevier
Objectives The primary aim of this study is to compare the effect of using tumor thickness
versus depth of invasion (DOI) to determine the 8th edition AJCC T-category on survival in a …

Nodal yield and survival in oral squamous cancer: Defining the standard of care

A Ebrahimi, WJ Zhang, K Gao, JR Clark - Cancer, 2011 - Wiley Online Library
BACKGROUND: Elective neck dissection (END) is commonly used as a staging and
therapeutic procedure for oral squamous cell carcinoma (SCC) at high risk of nodal …

Tumour infiltration depth⩾ 4 mm is an indication for an elective neck dissection in pT1cN0 oral squamous cell carcinoma

LJ Melchers, E Schuuring, BAC Van Dijk, GH De Bock… - Oral oncology, 2012 - Elsevier
Patients with pT1cN0 oral squamous cell carcinomas (OSCC) are generally not treated with
a neck dissection (ND). However, in 25% of cN0 patients, nodal metastases become …

Minimum nodal yield in oral squamous cell carcinoma: defining the standard of care in a multicenter international pooled validation study

A Ebrahimi, JR Clark, M Amit, TC Yen, CT Liao… - Annals of surgical …, 2014 - Springer
Purpose There is evidence to suggest that a nodal yield< 18 is an independent prognostic
factor in patients with clinically node negative (cN0) oral squamous cell carcinoma (SCC) …

Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer

V Patel, CA Marsh, RT Dorsam, CM Mikelis… - Cancer research, 2011 - AACR
Despite our improved understanding of cancer, the 5-year survival rate for head and neck
squamous cell carcinomas (HNSCC) patients remains relatively unchanged at 50% for the …